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| 中文名 | 夫西地酸钠 |
|---|---|
| 英文名 | Fusidic acid sodium salt |
| 中文别名 | 梭连链孢酸钠盐 |
| 英文别名 |
Sodium (3α,4α,5α,8α,9β,11α,13α,14β,16β,17Z)-16-acetoxy-3,11-dihydroxy-4,8,14-trimethyl-18-norcholesta-17,24-dien-21-oate
MFCD00865135 5-Heptenoic acid, 2-[(3α,4α,5α,8α,9β,11α,13α,14β,16β,17Z)-16-(acetyloxy)-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methyl-, sodium salt, (2Z)- (1:1) Sodium (2Z)-2-[(3α,4α,5α,8α,9β,11α,13α,14β,16β,17Z)-16-acetoxy-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methylhept-5-enoate (3a,4a,8a,9b,11a,13a,14b,16b,17Z)-16-(Acetyloxy)-3,11-dihydroxy-29-nordammara-17(20),24-dien-21-oic Acid Monosodium Salt sodium (2Z)-2-[(3α,4α,5α,8α,9β,11α,13α,14β,16β,17Z)-16-(acetyloxy)-3,11-dihydroxy-4,8,10,14-tetramethylgonan-17-ylidene]-6-methylhept-5-enoate EINECS 212-030-3 Fusidate Sodium Sodium fusidate Fusidic acid sodium Sodium 3a,11a,16b-Trihydroxy-29-nor-8a,9b,13a,14b-dammara-17(20),24-dien-21-oate 16-Acetate Fusidic acid sodium salt Fusidic acid (sodium salt) |
| 沸点 | 635.6ºC at 760 mmHg |
|---|---|
| 分子式 | C31H47NaO6 |
| 分子量 | 538.691 |
| 闪点 | 197.6ºC |
| 精确质量 | 538.327026 |
| PSA | 106.89000 |
| LogP | 4.33140 |
| 外观性状 | 白色结晶粉末 |
| 储存条件 | 2-8°C密封储存 |
| 水溶解性 | H2O: soluble |
| 计算化学 | 1、 氢键供体数量：2 2、 氢键受体数量：6 3、 可旋转化学键数量：6 4、 拓扑分子极性表面积（TPSA）：107 5、 重原子数量：38 6、 表面电荷：0 7、 复杂度：1000 8、 同位素原子数量：0 9、 确定原子立构中心数量：10 10、 不确定原子立构中心数量：0 11、 确定化学键立构中心数量：1 12、 不确定化学键立构中心数量：0 13、 共价键单元数量：2 |
| 更多 | 1. 性状：未确定 2. 密度（g/mL,25/4℃）：未确定 3. 相对蒸汽密度（g/mL,空气=1）：未确定 4. 熔点（ºC）：未确定 5. 沸点（ºC,常压）：未确定 6. 沸点（ºC,5.2kPa）：未确定 7. 折射率：未确定 8. 闪点（ºC）：未确定 9. 比旋光度（º）：未确定 10. 自燃点或引燃温度（ºC）：未确定 11. 蒸气压（kPa,25ºC）：未确定 12. 饱和蒸气压（kPa,60ºC）：未确定 13. 燃烧热（KJ/mol）：未确定 14. 临界温度（ºC）：未确定 15. 临界压力（KPa）：未确定 16. 油水（辛醇/水）分配系数的对数值：未确定 17. 爆炸上限（%,V/V）：未确定 18. 爆炸下限（%,V/V）：未确定 19. 溶解性：溶于水 |
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Section 1. Chemical Product and Company Identification Fusidic Acid Sodium Salt Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym
Chemical Name Chemical Family Fusidic Acid Sodium Salt Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs. Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationNot available. IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Not available. Flash Points Flammable LimitsNot available. Products of CombustionThese products are carbon oxides (CO, CO2). Some metallic oxides. Fire Hazards in Presence of Slightly flammable to flammable in presence of heat. Various Substances Risks of explosion of the product in presence of mechanical impact: Not available. Explosion Hazards in Risks of explosion of the product in presence of static discharge: Not available. Presence of Various Substances SMALL FIRE: Use DRY chemical powder. Fire Fighting Media LARGE FIRE: Use water spray, fog or foam. Do not use water jet. and Instructions Special Remarks onMaterial in powder form, capable of creating a dust explosion. As with most organic solids, fire is possible at elevated temperatures Fire Hazards Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. Hazards Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 7. Handling and Storage Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do Precautions not ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles such as oxidizing agents. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 8°C (46.4°F). Refrigerate. Fusidic Acid Sodium Salt Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be a Large Spillused to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Powdered solid.)OdorNot available. TasteNot available. Molecular Weight538.7g/mole White. Off-white. Color Not available. pH (1% soln/water) Boiling PointNot available. Not available. Melting Point Critical TemperatureNot available. Not available. Specific Gravity Vapor PressureNot applicable. Vapor DensityNot available. Not available. Volatility Odor ThresholdNot available. Not available. Water/Oil Dist. Coeff. Ionicity (in Water)Not available. Dispersion PropertiesSee solubility in water. SolubilityPartially soluble in cold water. Section 10. Stability and Reactivity Data StabilityThe product is stable. Not available. Instability Temperature Conditions of InstabilityExcess heat, incompatible materials, dust generation Incompatibility with various Reactive with oxidizing agents. substances CorrosivityNot available. Special Remarks onNot available. Reactivity Special Remarks onNot available. Corrosivity PolymerizationWill not occur. Fusidic Acid Sodium Salt Section 11. Toxicological Information Routes of EntryInhalation. Ingestion. Toxicity to AnimalsAcute oral toxicity (LD50): 840.5 mg/kg [Mouse]. Chronic Effects on Humans Not available. Other Toxic Effects onSlightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Humans Special Remarks onNot available. Toxicity to Animals Special Remarks onNot available. Chronic Effects on Humans Special Remarks on otherAcute Potential Health Effects: Toxic Effects on HumansSkin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: May cause gastrointestinal irritation or disturbances with nausea, vomiting, hypermotility, diarrhea.. May affect behavior/central nervous system (tremor, ataxia, somnolence), respiration (dyspnea), blood (leukopenia). It may also affect the liver. Section 12. Ecological Information EcotoxicityNot available. BOD5 and CODNot available. Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the ProductsThe products of degradation are less toxic than the product itself. of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). IdentificationNot applicable. Special Provisions forNot applicable. Transport DOT (Pictograms) Fusidic Acid Sodium Salt Section 15. Other Regulatory Information and Pictograms No products were found. Federal and State Regulations CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has Proposition 65found to cause cancer which would require a warning under the statute: No products were found. Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsEINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No. 212-030-3). Canada: Listed on Canadian Domestic Substance List (DSL). China: Not listed on National Inventory. Japan: Not listed on National Inventory (ENCS). Korea: Not listed on National Inventory (KECI). Philippines: Not listed on National Inventory (PICCS). Australia: Listed on AICS. Other ClassificationsWHMIS (Canada) Not controlled under WHMIS (Canada). DSCL (EEC)R22- Harmful if swallowed.S46- If swallowed, seek medical advice immediately and show this container or label. Health Hazard HMIS (U.S.A.)1 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 1 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Fusidic Acid Sodium Salt SECTION 16 - ADDITIONAL INFORMATION N/A |
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毒理学数据: 1、急性毒性：小鼠口经LD50：975mg/kg； 2、急性毒性：小鼠腹腔LD50：170mg/kg； 3、急性毒性：小鼠静脉LD50：205mg/kg； 4、急性毒性：小鼠皮下LD50：313mg/kg；大鼠皮下LD50：>1mg/kg
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| 符号 |
GHS07 |
|---|---|
| 信号词 | Warning |
| 危害声明 | H302 |
| 警示性声明 | P301 + P312 + P330 |
| 个人防护装备 | dust mask type N95 (US);Eyeshields;Gloves |
| 危害码 (欧洲) | Xn:Harmful; |
| 风险声明 (欧洲) | R22 |
| 安全声明 (欧洲) | 26-36 |
| 危险品运输编码 | NONH for all modes of transport |
| WGK德国 | 3 |
| RTECS号 | LV5775000 |
| 海关编码 | 2942000000 |
| 海关编码 | 2942000000 |
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