101314-97-0

• 常用中文名：辛伐他汀钠盐
• 常用英文名：Simvastatin Hydroxy Acid Sodium Salt
• CAS号：101314-97-0
• 分子式：C₂₅H₃₉NaO₆
• 分子量：458.563
• 相关类别： 信号通路 代谢酶/蛋白酶 HMG-CoA还原酶(HMGCR)
• 发布时间：2018-10-17 14:59:47
• 更新时间：2026-07-01 17:03:16
• Simvastatin sodium 是内酯的前药,可通过非特异性羧酯酶或非酶促过程水解为活性羟基酸。Simvastatin sodium 对 HMG-CoA 还原酶的抑制作用,其 Ki 值为 0.12 nM。

名称

• 中文名: 辛伐他汀钠盐
• 英文名: sodium,(3R,5S)-7-[(1R,2R,6S,8S)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
• 中文别名: 辛伐他汀羟酸(钠盐); 辛伐他汀杂质01(NA); (3R,5R)-7-((1S,2S,6R,8S,8-8-((2,2-二甲基丁酰基)氧基)-2,6-二甲基-1,2,6,7,8,8A-六氢萘-1-基)-3,5-二羟基庚酸钠; 辛伐他汀杂质A钠盐; 辛伐他汀酸钠; 辛伐他汀相关化合物A; 辛伐他汀杂质1 钠盐(辛伐他汀杂质A钠盐); 辛伐他汀钠; 辛伐他汀杂质钠盐; 辛伐他汀羟基酸钠; 辛伐他汀羟基酸的钠盐标准品; 化合物:Simvastatin (sodium salt); 羟基辛伐他汀酸钠; 化合物：Simvastatin (sodium salt); 辛伐他汀羟基酸钠盐-D6; 辛伐他汀杂质A 标准品; 辛伐他汀羟基酸钠盐; 辛伐他汀杂质A
• 英文别名: (3R,5R)-7-[(1S,2S,6R,8S,8-8-[(2,2-Dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphth; Sodium (3R,5R)-7-{(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl}-3,5-dihydroxyheptanoate; Simvastati; SimvastatinImpurityA-d6SodiumSalt; IMp. A as SodiuM Salt: (3R,5R)-7-[(1S,2S,6R,8S,8-8-[(2,2-DiMethylbutanoyl)oxy]-2,6-diMethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyhtanoic Acid SodiuM Salt (Tenivastatin SodiuM Salt; SIMVASTATIN HYDROXY ACID SODIUM SALT; Simvastatin hydroxyl acid D6 Sodium salt; simvastatin sodium salt; Simvastatin Impurity 1 Sodium Salt(Simvastatin Impurity A Sodium Salt); Simvasatin Imp A; Simvastatin Impurity A sodium salt（）; (3R,5R)-7-[(1S,2S,6R,8S,8-8-[(2,2-Dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyhtanoic Acid Sodium Salt; Simvastatin hydroxy acid sodium; Simvastatin Impurity A as Sodium Salt; simvastatin sodium; Simvastatin Impurity A Sodium Salt; trianilino-methyl-silane; Silanetriamine,1-methyl-N,N',N''-triphenyl; simivastin sodium salt; Simvastatin Impurity 1(Simvastatin Impurity A); Simvastatin Impurity 1（-A）; Simvastatin Impurity as Sodium Salt; sodium,(3R,5S)-7-[(1R,2R,6S,8S)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyhtanoate; Simvastatin Impurity 1; 1-Naphthalenehtanoic acid,8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-b,d-dihydroxy-2,6-dimethyl-, monosodium salt, [1S-[1a(bS*,dS*),2a,6b,8b,8aa]]; Si-Methyl-N,N'N''-triphenyl-silantriyltriamin; Simvastatin Acid Sodium Salt; 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, sodium salt, (βR,δR,1S,2S,6R,8S,8aR)- (1:1); SIMVASTATIN, SODIUM SALT; Methyl-tris-anilino-silan; Simvastatin hydroxyl acid sodium salt-d6; Simvasatin Impurity A/ Simvasatin Related Compound A (Simvastatin Sodium/ Tenivastatin Sodium); Simvastatin Impurityodium Salt; Simvastatin Impurity AQ: What is Simvastatin Impurity A Q: What is the CAS Number of Simvastatin Impurity A Q: What is the storage condition of Simvastatin Impurity A Q: What e the applications of Simvastatin Impurity A; Simvastatin EP Impurity A Sodium Salt; Sodium (3R,5R)-7-((1S,2S,6R,8S,8-8-((2,2-dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyhtanoate; SiMvastatin IMp. A as SodiuM Salt; Sodium (3R,5R)-7-{(1S,2S,6R,8S,8-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl}-3,5-dihydroxyhtanoate

物化性质

• 分子式: C₂₅H₃₉NaO₆
• 分子量: 458.563
• 精确质量: 458.264435
• PSA: 106.89000
• LogP: 2.77100
• 储存条件: 2-8°C，密封，干燥

生物活性

• 描述: Simvastatin sodium 是内酯的前药,可通过非特异性羧酯酶或非酶促过程水解为活性羟基酸。Simvastatin sodium 对 HMG-CoA 还原酶的抑制作用,其 Ki 值为 0.12 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> HMG-CoA还原酶(HMGCR)
  研究领域 >> 其他
  研究领域 >> 炎症/免疫
• 体外研究: 辛伐他汀钠对人淋巴母细胞和SV40转化的MRC成纤维细胞中HMG-CoA还原酶有抑制作用[1]。辛伐他汀钠(100μM)可抑制Na~+H~+antiport活性,导致细胞内pH值下降,细胞增殖减少,而甲羟戊酸盐(mevalonate)可阻止这种抑制作用,而不是多利醇(dolichol)或角鲨烯[1]。
• 体内研究: 辛伐他汀钠(口服；8 mg/kg；18天)可降低血浆胆固醇水平33%,辛伐他汀可与依西替米联合治疗血脂异常[1]。
• 参考文献:

  [1]. Corsini A, et al. Pharmacology of competitive inhibitors of HMG-CoA reductase.Pharmacol Res. 1995 Jan;31(1):9-27.

合成路线

79902-63-9 ~80% 101314-97-0

文献：Griffin, John; Lanza, Guido; Yu, Jessen Patent: US2005/261354 A1, 2005 ; Location in patent: Page/Page column 53 ; US 20050261354 A1

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