101314-97-0
101314-97-0 structure
- Name: Simvastatin Hydroxy Acid Sodium Salt
- Chemical Name: sodium,(3R,5S)-7-[(1R,2R,6S,8S)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate
- CAS Number: 101314-97-0
- Molecular Formula: C25H39NaO6
- Molecular Weight: 458.563
- Catalog: Signaling Pathways Metabolic Enzyme/Protease HMG-CoA Reductase (HMGCR)
- Create Date: 2018-10-17 14:59:47
- Modify Date: 2026-07-01 17:03:16
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Simvastatin sodium is a lactone prodrug, can be hydrolysed to active hydroxy-acid by non-specific carboxyesterases or non-enzymatic processes. Simvastatin sodium shows a inhibition of HMG-CoA reductase with a Ki value of 0.12 nM[1][2].
| Name | sodium,(3R,5S)-7-[(1R,2R,6S,8S)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate |
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| Synonyms |
(3R,5R)-7-[(1S,2S,6R,8S,8-8-[(2,2-Dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphth
Sodium (3R,5R)-7-{(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl}-3,5-dihydroxyheptanoate Simvastati SimvastatinImpurityA-d6SodiumSalt IMp. A as SodiuM Salt: (3R,5R)-7-[(1S,2S,6R,8S,8-8-[(2,2-DiMethylbutanoyl)oxy]-2,6-diMethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyhtanoic Acid SodiuM Salt (Tenivastatin SodiuM Salt SIMVASTATIN HYDROXY ACID SODIUM SALT Simvastatin hydroxyl acid D6 Sodium salt simvastatin sodium salt Simvastatin Impurity 1 Sodium Salt(Simvastatin Impurity A Sodium Salt) Simvasatin Imp A Simvastatin Impurity A sodium salt（） (3R,5R)-7-[(1S,2S,6R,8S,8-8-[(2,2-Dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyhtanoic Acid Sodium Salt Simvastatin hydroxy acid sodium Simvastatin Impurity A as Sodium Salt simvastatin sodium Simvastatin Impurity A Sodium Salt trianilino-methyl-silane Silanetriamine,1-methyl-N,N',N''-triphenyl simivastin sodium salt Simvastatin Impurity 1(Simvastatin Impurity A) Simvastatin Impurity 1（-A） Simvastatin Impurity as Sodium Salt sodium,(3R,5S)-7-[(1R,2R,6S,8S)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyhtanoate Simvastatin Impurity 1 1-Naphthalenehtanoic acid,8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-b,d-dihydroxy-2,6-dimethyl-, monosodium salt, [1S-[1a(bS*,dS*),2a,6b,8b,8aa]] Si-Methyl-N,N'N''-triphenyl-silantriyltriamin Simvastatin Acid Sodium Salt 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, sodium salt, (βR,δR,1S,2S,6R,8S,8aR)- (1:1) SIMVASTATIN, SODIUM SALT Methyl-tris-anilino-silan Simvastatin hydroxyl acid sodium salt-d6 Simvasatin Impurity A/ Simvasatin Related Compound A (Simvastatin Sodium/ Tenivastatin Sodium) Simvastatin Impurityodium Salt Simvastatin Impurity AQ: What is Simvastatin Impurity A Q: What is the CAS Number of Simvastatin Impurity A Q: What is the storage condition of Simvastatin Impurity A Q: What e the applications of Simvastatin Impurity A Simvastatin EP Impurity A Sodium Salt Sodium (3R,5R)-7-((1S,2S,6R,8S,8-8-((2,2-dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyhtanoate SiMvastatin IMp. A as SodiuM Salt Sodium (3R,5R)-7-{(1S,2S,6R,8S,8-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl}-3,5-dihydroxyhtanoate |
| Description | Simvastatin sodium is a lactone prodrug, can be hydrolysed to active hydroxy-acid by non-specific carboxyesterases or non-enzymatic processes. Simvastatin sodium shows a inhibition of HMG-CoA reductase with a Ki value of 0.12 nM[1][2]. |
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| Related Catalog | |
| In Vitro | Simvastatin sodium shows a inhibition of HMG-CoA reductase in human lymphoblasts and SV40 transformed MRCS fibroblasts[1]. Simvastatin sodium (100 μM) inhibits the Na+/H+ antiport activity leading to a fall of intracellular pH and to a reduced cell proliferation.And the inhibitory effect is prevented by mevalonate but not dolichol or squalene[1]. |
| In Vivo | Simvastatin sodium (oral administration; 8 mg/kg; 18 days) reduces plasma cholesterol levels 33%, simvastatin can be used in combination with ezetimibe to treat dyslipidemia[1]. |
| References |
| Molecular Formula | C25H39NaO6 |
|---|---|
| Molecular Weight | 458.563 |
| Exact Mass | 458.264435 |
| PSA | 106.89000 |
| LogP | 2.77100 |
|
~80%
101314-97-0 |
| Literature: Griffin, John; Lanza, Guido; Yu, Jessen Patent: US2005/261354 A1, 2005 ; Location in patent: Page/Page column 53 ; US 20050261354 A1 |
| Precursor 1 | |
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| DownStream 0 | |