96-24-2

96-24-2结构式

常用中文名：3-氯-1,2-丙二醇
常用英文名：3-Chloro-1,2-propanediol
CAS号：96-24-2
分子式：C₃H₇ClO₂
分子量：110.539
相关类别：生物化工植物提取物
发布时间：2018-03-15 08:00:00
更新时间：2024-01-03 01:32:53
【用途一】
主要用作醋酸纤维等的溶剂，还用于制备增塑剂、表面活性剂、染料中间体和药物等
【用途二】
用作染料中间体
【用途三】
用于有机合成。药物喘定的中间体；用作醋酸纤维等的溶剂，也用作增塑剂、表面活性剂、染料的中间体。

中文名	(±)-3-氯-1,2-丙二醇
英文名	3-chloropropane-1,2-diol
中文别名	α-氯甘油 α-氯丙二醇 3-氯-1,2-丙二醇
英文别名	N-[4-Chloro-3-(trifluoromethyl)phenyl]-N’-[[3-(4-fluorophenyl)-3,4-dihydro 3-MCPD EINECS 202-492-4 3-chloropropane-1,2-diol Glycerol α-monochlorohydrin a-chlorohydrin UNII:QGS78A3T6P Glycerol a-Monochlorohydrin α-Chlorohydrin 3-Chlorpropan-1,2-diol 3-Chloro-1,2-propanediol a-Monochlorohydrin MFCD00004712 3-monochloropropane-1,2-diol (RS)-3-chloropropylene glycol 1,2-Propanediol, 3-chloro- b,b'-Dihydroxyisopropyl Chloride

密度	1.3±0.1 g/cm3
沸点	213.0±0.0 °C at 760 mmHg
熔点	-40ºC
分子式	C₃H₇ClO₂
分子量	110.539
闪点	113.3±21.8 °C
精确质量	110.013458
PSA	40.46000
LogP	-0.76
外观性状	无色透明液体
蒸汽压	0.0±0.9 mmHg at 25°C
折射率	1.474
储存条件	储存于阴凉、通风的库房。远离火种、热源。防止阳光直射。保持容器密封。应与氧化剂、碱类、食用化学品分开存放，切忌混储。配备相应品种和数量的消防器材。储区应备有泄漏应急处理设备和合适的收容材料。
稳定性	1.避免光照、接触潮湿空气，避免与强氧化剂、强碱接触。有吸湿性，见光或久置逐渐变为黄色。长时间与湿气接触时逐渐分解为酸。化学性质：3-氯-1,2-丙二醇加热至140~142℃时部分发生分解。用浓硝酸氧化生成3-氯代乳酸。在稀硝酸溶液中用高碘酸钾氧化生成氯代乙醛。3-氯-1,2-丙二醇脱氯化氢生成缩水甘油。与水长时间回流时逐渐水解生成甘油。在与伯醇相当的烷氧基金属化合物作用下，生成甘油-α-一烷基醚。 2.存在于烟气中。
水溶解性	Soluble
凝固点	-40℃
分子结构	1、摩尔折射率：23.82 2、摩尔体积（cm³/mol）：84.8 3、等张比容（90.2K）：220.7 4、表面张力（dyne/cm）：45.8 5、介电常数： 6、偶极距（10^-24cm³）： 7、极化率：9.44
计算化学	1.疏水参数计算参考值（XlogP）:-0.5 2.氢键供体数量:2 3.氢键受体数量:2 4.可旋转化学键数量:2 5.互变异构体数量:无 6.拓扑分子极性表面积40.5 7.重原子数量:6 8.表面电荷:0 9.复杂度:32 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:1 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1. 性状：无色液体，放置后逐渐变成微带绿色的黄色液体，有愉快气味。 2. 相对密度（g/mL,20/4℃）：1.3204 3. 沸点（ºC，分解）：213 4. 沸点（ºC,1.466kpa）：116 5. 熔点（ºC）：-40 6. 折射率（n20ºC）：1.4809 7. 黏度（mPa·s,20ºC）：159 8. 闪点（ºC,开口）：137.8 9. 燃烧热（KJ/mol,20ºC）：1680.6 10. 蒸气压（kPa,141ºC）：5.33 11. 蒸气压（kPa,113ºC）：1.33 12. 蒸气压（kPa,83ºC）：0.133 13. 液相标准声称热(焓)( kJ·mol^-1)：-525.3 14. 溶解性：溶于水、乙醇、乙醚和丙酮。微溶于甲苯，不溶于苯、石油醚和四氯化碳。

第一部分：化学品名称

化学品中文名称：	3-氯-1，2-丙二醇；3-氯-1，2-二羟基丙烷
化学品英文名称：	3-Chloro-1，2-propanediol；Chlorhydrin
中文俗名或商品名：
Synonyms：
CAS No.：	96-24-2
分子式：	C₃H₇ClO₂
分子量：	110.55

第二部分：成分/组成信息

纯化学品混合物

化学品名称：3-氯-1，2-丙二醇；3-氯-1，2-二羟基丙烷

有害物成分

含量

CAS No.

第三部分：危险性概述

危险性类别：	第6．1类毒害品
侵入途径：	吸入食入经皮吸收
健康危害：	吸入、摄入或经皮肤吸收后会中毒。对肺、肝、肾和脑都有影响。吸入蒸气能产生恶心、头痛、呕吐、眩晕、昏迷等症状。吸入蒸气可致肺水肿，严重者可致死。
环境危害：
燃爆危险：

第四部分：急救措施

皮肤接触：	用肥皂水及清水彻底冲洗。就医。
眼睛接触：	拉开眼睑，用流动清水冲洗15分钟。就医。
吸入：	脱离现场至空气新鲜处。呼吸困难时给输氧。呼吸停止时，立即进行人工呼吸。就医。
食入：	误服者，饮适量温水，催吐。就医。

第五部分：消防措施

危险特性：	遇明火、高热易燃。受高热分解，放出有毒的烟气。
有害燃烧产物：
灭火方法及灭火剂：	雾状水、抗溶性泡沫、二氧化碳、干粉。
消防员的个体防护：
禁止使用的灭火剂：
闪点(℃)：	58
自燃温度(℃)：
爆炸下限[%(V/V)]：
爆炸上限[%(V/V)]：
最小点火能(mJ)：
爆燃点：
爆速：
最大燃爆压力(MPa)：
建规火险分级：

第六部分：泄漏应急处理

应急处理：

疏散泄漏污染区人员至安全区，禁止无关人员进入污染区，建议应急处理人员戴自给式呼吸器，穿化学防护服。不要直接接触泄漏物，用砂土、蛭石或其它惰性材料吸收，收集运至废物处理场所。用水刷洗泄漏污染区，对污染地带进行通风。如大量泄漏，利用围堤收容，然后收集、转移、回收或无害处理后废弃。

第七部分：操作处置与储存

操作注意事项：
储存注意事项：

第八部分：接触控制/个体防护

最高容许浓度：	中国 MAC：未制订标准前苏联 MAC：未制订标准美国TLV—TWA：未制订标准
监测方法：
工程控制：	密闭操作，局部排风。尽可能机械化、自动化。
呼吸系统防护：	可能接触其蒸气时，应该佩戴防毒口罩。紧急事态抢救或逃生时，佩戴自给式呼吸器。
眼睛防护：	戴化学安全防护眼镜。
身体防护：	穿相应的防护服。
手防护：	戴防化学品手套。
其他防护：	工作现场禁止吸烟、进食和饮水。工作后，淋浴更衣。保持良好的卫生习惯。避免高浓度吸入。

第九部分：理化特性

外观与性状：	无色粘稠液体，有吸湿性。
pH：
熔点(℃)：	-40
沸点(℃)：	139／2．39kPa
相对密度(水=1)：	1．3218
相对蒸气密度(空气=1)：
饱和蒸气压(kPa)：	0．133／83℃
燃烧热(kJ/mol)：
临界温度(℃)：
临界压力(MPa)：
辛醇/水分配系数的对数值：
闪点(℃)：	58
引燃温度(℃)：
爆炸上限%(V/V)：
爆炸下限%(V/V)：
分子式：	C₃H₇ClO₂
分子量：	110.55
蒸发速率：
粘性：
溶解性：	溶于水、甲醇、甘油、乙醚、丙酮、乙酸乙酯等。
主要用途：	用作醋酸纤维素的溶剂，并用于制增塑剂、表面活性剂、染料、药物、甘油衍生物等。

第十部分：稳定性和反应活性

稳定性：	在常温常压下稳定
禁配物：	强氧化剂、强碱。
避免接触的条件：	光照、接触潮湿空气。
聚合危害：	不能出现
分解产物：	—氧化碳、二氧化碳、氯化氢。

第十一部分：毒理学资料

急性毒性：	LD50：26mg／kg(大鼠经口) LC50：
急性中毒：
慢性中毒：
亚急性和慢性毒性：
刺激性：
致敏性：
致突变性：
致畸性：
致癌性：

第十二部分：生态学资料

生态毒理毒性：
生物降解性：
非生物降解性：
生物富集或生物积累性：

第十三部分：废弃处置

废弃物性质：
废弃处置方法：
废弃注意事项：

第十四部分：运输信息

危险货物编号：	61586
UN编号：	2689
包装标志：
包装类别：	Ⅱ
包装方法：
运输注意事项：	储存于阴凉、干燥、通风良好的库房。远离火种、热源。保持容器密封。防止受潮和雨淋。应与氧化剂、碱类、食用化工原料分开存放。不能与粮食、食物、种子、饲料、各种日用品混装、混运。储存间内的照明、通风等设施应
RETCS号：
IMDG规则页码：

第十五部分：法规信息

国内化学品安全管理法规：
国际化学品安全管理法规：

第十六部分：其他信息

参考文献：	1.周国泰，化学危险品安全技术全书，化学工业出版社，1997 2.国家环保局有毒化学品管理办公室、北京化工研究院合编，化学品毒性法规环境数据手册，中国环境科学出版社.1992 3.Canadian Centre for Occupational Health and Safety,CHEMINFO Database.1998 4.Canadian Centre for Occupational Health and Safety, RTECS Database, 1989
填表时间：	年月日
填表部门：
数据审核单位：
修改说明：
其他信息：	5
MSDS修改日期：	年月日

毒理学数据:

1、急性毒性：大鼠经口LD50：150mg/kg，小鼠经口LD50：150mg/kg，大鼠吸入MLC为125mg/m3

生态学数据:

该物质对环境有危害，应特别注意对水体的污染。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TY4025000

CHEMICAL NAME :: 1,2-Propanediol, 3-chloro-

CAS REGISTRY NUMBER :: 96-24-2

BEILSTEIN REFERENCE NO. :: 0635684

LAST UPDATED :: 199806

DATA ITEMS CITED :: 59

MOLECULAR FORMULA :: C3-H7-Cl-O2

MOLECULAR WEIGHT :: 110.55

WISWESSER LINE NOTATION :: Q1YQ1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 26 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 125 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Behavioral - ataxia

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >90 ppm/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - changes in structure or function of salivary glands Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 73 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 82 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - general anesthetic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 23700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 34580 mg/kg/72W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2500 ug/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 85500 ug/kg

SEX/DURATION :: male 9 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 13200 ug/kg

SEX/DURATION :: male 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 150 mg/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 14 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 24 mg/kg

SEX/DURATION :: male 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 90 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 750 mg/kg

SEX/DURATION :: female 15 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 150 mg/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 133 mg/kg

SEX/DURATION :: male 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 90 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 70 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 240 mg/kg

SEX/DURATION :: male 30 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intratesticular

DOSE :: 2667 ug/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intratesticular

DOSE :: 15385 ug/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1260 mg/kg

SEX/DURATION :: male 42 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5600 mg/kg

SEX/DURATION :: male 40 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intratesticular

DOSE :: 40 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 24 mg/kg

SEX/DURATION :: male 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 25 mg/kg

SEX/DURATION :: male 25 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 mg/kg

SEX/DURATION :: male 5 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 350 mg/kg

SEX/DURATION :: male 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 280 mg/kg

SEX/DURATION :: male 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 132 mg/kg

SEX/DURATION :: female 1 day(s) after conception

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 132 mg/kg

SEX/DURATION :: male 2 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 750 mg/kg

SEX/DURATION :: male 50 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 450 mg/kg

SEX/DURATION :: male 18 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 625 mg/kg

SEX/DURATION :: male 25 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 75 mg/kg

SEX/DURATION :: male 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 75 mg/kg

SEX/DURATION :: male 3 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 60 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Sperm Morphology

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TEST SYSTEM :: Mammal - species unspecified

DOSE/DURATION :: 692 mg/kg/30D

REFERENCE :: FOBGA8 Folia Biologica (Krakow). (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1953- Volume(issue)/page/year: 22,281,1974 *** REVIEWS *** TOXICOLOGY REVIEW LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 23,1625,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84042 No. of Facilities: 5 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 20 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84042 No. of Facilities: 43 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 2917 (estimated)

符号	GHS05, GHS06, GHS08
信号词	Danger
危害声明	H300-H312-H318-H331-H351-H360
警示性声明	P201-P261-P264-P280-P301 + P310-P305 + P351 + P338
个人防护装备	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
危害码 (欧洲)	T:Toxic
风险声明 (欧洲)	R23/24/25;R36;R39;R60
安全声明 (欧洲)	S26-S28-S36/37/39-S38-S45-S53
危险品运输编码	UN 2689
WGK德国	3
RTECS号	TY4025000
包装等级	III
危险类别	6.1
海关编码	2905590090

上游产品 10
56-81-5 94266-20-3 106-20-7 106-89-8
107-05-1 110-89-4 90-15-3 67-56-1
2463-45-8 110-91-8
下游产品 10
104177-41-5 1072-61-3 1087-06-5 111038-24-5
57090-45-6 60827-45-4 557-25-5 57044-25-4
60456-23-7 40137-22-2

1、由甘油经氯化而得。将甘油和乙酸加入反应锅，搅拌加热至90-95℃，通干燥的氯化氢气体，至反应液增重至150%（理论值）即为终点。减压蒸馏，得粗品。再分馏，收集128-132℃（1.33-2.67kPa）馏分得3-氯-1,2-丙二醇。

2、由环氧氯丙烷水解而得。将环氧氯丙烷加入反应锅内，搅拌，加入稀硫酸使反应液呈酸性，升温，回流1h，将所得产物减压精馏即得成品。原料消耗定额：环氧氯丙烷（>95%）1200kg/t、硫酸3kg/t。

精制方法：减压蒸馏精制。

3.制法：

于装有搅拌器、温度计、滴液漏斗、回流冷凝器的反应瓶中，加入水120mL，浓硫酸1mL，加入至80℃，慢慢滴加环氧氯丙烷^①（2）120g(1.3mol),加完后继续于90℃搅拌反应1.5h，以使反应完全。减压浓缩除去其中的水，最后收集137～140℃/2.4kPa的馏分，得3-氯-1,2-丙二醇100g，收率70%。注：①环氧氯丙烷的水解为放热反应，滴加速度不宜太快，否则会因剧烈反应而使反应物冲出反应瓶。

海关编码	2905590090
中文概述	2905590090 其他无环醇的卤化、磺化等衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%
申报要素	品名, 成分含量, 用途, 包装
Summary	2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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