73168-24-8

• 常用中文名：(d(CH2)51,Tyr(Me)2,Arg8)-血管加压素
• 常用英文名：(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin trifluoroacetate salt
• CAS号：73168-24-8
• 分子式：C₅₂H₇₄N₁₄O₁₂S₂
• 分子量：1151.36
• 相关类别： 信号通路 G 蛋白偶联受体/G 蛋白 血管加压素受体
• 发布时间：2018-12-28 16:52:51
• 更新时间：2026-06-30 21:48:04
• (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin (SKF 100273) 是一种vasopressin V1 受体选择性拮抗剂。

名称

• 中文名: (D(CH2)51,TYR(ME)2,ARG8)-VASOPRESSIN
• 英文名: 3-mercapto-3-methyl-butyryl-tyr(me)-phe-gln-asn-cys-pro-arg-gly-nh2
• 中文别名: (D(CH2)51,TYR(ME)2,G8)-血管加压素; 化合物 (D(CH2)51,TYR(ME)2,G8)-VASOPRESSIN
• 英文别名: [PMP1,TYR(ME)2]-G8-VASOPRESSIN; (beta-Mercapto-beta,beta-cyclopentamethylene-propionyl(sup 1),o-me-Tyr(sup 2),g(sup 8))-vasopressin; 1-(beta-Mercapto-beta,beta-cyclopentamethylenropionic acid)-2-(o-methyl-Tyr)-gipressin; (B-mercapto-B,B-cyclopentamethyl-*enropionyl1,O; 3-MERCAPTO-3-METHYL-BUTYRYL-TYR(ME)-PHE-GLN-ASN-CYS-PRO-G-GLY-NH2; [PMP1,TYR(OME)2,G8] VASOPRESSIN; (B-MERCAPTO-B,B-CYCLOPENTAMETHYLENROPIONYL1,0-ME-TYR2, G8)- VASOPRESSIN); [1-MERCAPTOCYCLOHEXYL]ACETYL-TYR[O-METHYL]-PHE-GLN-ASN-CYS-PRO-G-GLY-NH2; sk&f100273; N-[1-Mercaptocyclohexylacetyl]-O-methyl-L-Tyr-L-Phe-L-Glu(NH2)-L-Asp(NH2)-L-Cys-L-Pro-L-g-Gly-NH2; 3-MERCAPTO-3-METHYLBUTYRYL-TYR[O-METHYL]-PHE-GLN-ASN-CYS-PRO-G-GLY-NH2; BETA-MERCAPTO-BETA,BETA-CYCLOPENTAMETHYLENE-PROPIONYL-TYR(ME)-PHE-GLN-ASN-CYS-PRO-G-GLY-NH2; [d(CH2)5,Tyr(Me)2]ginine vasopressin; Avpa; MANNING COMPOUND; 1-(beta-Mercapto-beta,beta-cyclopentamethylenropionic acid)-2-o-methyltyrosyl-8-ginine vasopressin; PMP-TYR(ME)-PHE-GLN-ASN-CYS-PRO-G-GLY-NH2, PMP1-CYS6, CYCLIC; (D(Ch2)5-o-me-Tyr-g)vasopressin; AVPX; Aavp; [D(CH2)51, TYR(ME)2, VAL4, G8]-VASOPRESSIN; [DEAMINO-PEN1, O-ME-TYR2,G8]-VASOPRESSIN; (D(CH2)(5/1),TYR(ME)2,G8)-VASOPRESSIN; Cgp; [Pmp1, Tyr(Me)2]-g8-Vasopressin (0.5 mg vial); [(3-Mercapto-3,3-pentamethylenropionic acid)1,O-Methyl-Tyr2]AVP; (B-MERCAPTO-B,B-CYCLOPENTAMETHYL-*ENRO PIONYL1,O-M; gipressin, (beta-mercapto)beta,beta-cyclopentamethylenropionic acid(1)-o-methyl-Tyr; ginine vasopressin, beta-mercapto-(beta,beta-cyclopentamethylenropionic acid)(1)-methyl-Tyr; PMP-TYR(ME)-PHE-GLN-ASN-CYS-PRO-G-GLY-NH2; (DEAMINO-PEN1,TYR(ME)2,G8)-VASOPRESSIN; (d(CH)1,Tyr(Me)2,g)-Vasopressin; b-Mercapto-b,b-cyclopentaMethylene-propionyl-Tyr(Me)-Phe-Gln-Asn-Cys-Pro-g-Gly-NH2; Glycinamide, N-[2-(1-mercaptocyclohexyl)acetyl]-O-methyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-aspaginyl-L-cysteinyl-L-prolyl-L-ginyl-, cyclic (1→5)-disulfide; [d(CH2)5,Tyr(Me)2]AVP; (d(CH),Tyr(Me),g)-Vasopressin trifluoroacetate salt; vasopressin mercaptocyclohexaneacetic acid, MeTyr-8-L-g; [BETA-MERCAPTO-BETA,BETA-CYCLOPENTAMETHYLENROPIONYL1,O-ME-TYR2,G8]-VASOPRESSIN; N-[1-Mercaptocyclohexylacetyl]-O-methyl-L-Tyr-L-Phe-L-Gln-L-Asn-L-Cys-L-Pro-L-g-Gly-NH2; (d(CH2)51,Tyr(Me)2,A

物化性质

• 密度: 1.5 g/cm3
• 分子式: C₅₂H₇₄N₁₄O₁₂S₂
• 分子量: 1151.36
• 精确质量: 1150.51000
• PSA: 475.01000
• LogP: 3.52940
• 外观性状: 白色冻干的粉末
• 折射率: 1.695

生物活性

• 描述: (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin (SKF 100273) 是一种vasopressin V1 受体选择性拮抗剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 血管加压素受体
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Arai Y, et al. New topics in vasopressin receptors and approach to novel drugs: research and development of conivaptan hydrochloride (YM087), a drug for the treatment of hyponatremia. J Pharmacol Sci. 2009 Jan;109(1):53-9.

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H332
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R20
• 安全声明 (欧洲): 36
• 危险品运输编码: NONH for all modes of transport