361442-04-8

• 常用中文名：沙克列汀
• 常用英文名：saxagliptin
• CAS号：361442-04-8
• 分子式：C₁₈H₂₅N₃O₂
• 分子量：315.410
• 相关类别： 原料药 循环系统用药 调节血脂药
• 发布时间：2018-08-12 11:20:32
• 更新时间：2026-07-04 18:10:38
• Saxagliptin(BMS477118)是选择性可逆的DPP4抑制剂,IC50和Ki分别为26 nM和1.3 nM。

名称

• 中文名: 沙格列汀
• 英文名: Saxagliptin
• 中文别名: 13C-沙格列汀盐酸盐; 萨克列汀; 沙格列汀(沙克列汀),(1S,3S,5S)-2-[(2S)-2-氨基-2-(3-羟基三环[3.3.1.13; 沙格列汀及中间体; 沙格列汀-13C-D2 盐酸; 沙格列汀(沙克列汀),(1S,3S,5S)-2-[(2S)-2-氨基-2-(3-羟基三环[3.3.1.13,7]癸烷-1-基)乙酰基]-2-氮杂双环[3.1.0]己烷-3-腈; [13C2,15N]-沙格列汀; 盐酸沙格列汀中间体; 沙沙利汀; 沙格列汀原料药; 沙格列汀游离碱; 沙克列汀, 选择性可逆的DPP4抑制剂; (1S,3S,5S)-2-[(2S)-2-氨基-2-(3-羟基三环[3.3.1.13,7]癸烷-1-基)乙酰基]-2-氮杂双环[3.1.0]己烷-3-腈; 沙格列汀,(1S,3S,5S)-2-[(2S)-2-氨基-2-(3-羟基三环[3.3.1.13,7]癸烷-1-基)乙酰基]-2-氮杂双环[3.1.0]己烷-3-腈; 沙格列汀/沙克列汀; 沙格列汀,10 MM DMSO 溶液; (1S,3S,5S)-2-[(2S)-2-氨基-2-(3-羟基金刚烷-1-基)乙酰基]-2-氮杂双环[3.1.0]己烷-3-腈; (1S,3S,5S)-2-((2S)-2-氨基-2-(3-羟基金刚烷-1-基)乙酰基)-2-氮杂双环[3.1.0]己烷-3-甲腈; 沙格列汀代码杂质; 沙克列汀,沙格列汀; Antidiabetic18沙格列汀; 沙格列汀相关杂质; 沙G列汀
• 英文别名: Saxagliptin for system suitability CRS; [13C2,15N]-Saxagliptin; 13C-Saxagliptin HCl; SaxagliptinQ: What is Saxagliptin Q: What is the CAS Number of Saxagliptin Q: What is the storage condition of Saxagliptin Q: What e the applications of Saxagliptin; (1S,3S,5S)-2-{(2S)-2-Amino-2-[(1r,3R,5R,7S)-3-hydroxyadamantan-1-yl]acetyl}-2-azabicyclo[3.1.0]hexane-3-carbonitrile; Saxagliptin 15ND2; xagliptin; Salkeliptin impurity; (1R,3S,5R)-2-((S)-2-amino-2-((1r,3R,5R,7S)-3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile; Saxagliptin BMS 477118 Onglyza; Saxagliptin (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; Saxagliptin, >=; Saxagliptin-13C,d2 TFA SaltQ: What is Saxagliptin-13C,d2 TFA Salt Q: What is the CAS Number of Saxagliptin-13C,d2 TFA Salt; Saxagliptin, 10 mM in DMSO; Saxagliptin HCl; 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1S,3S,5S); Onglyza; Saxagliptin 13C D2 HClQ: What is Saxagliptin 13C D2 HCl Q: What is the CAS Number of Saxagliptin 13C D2 HCl; (1s,3s,5s)-2-((s)-2-amino-2-((1r,3r,5r,7s)-3-hydroxyadamantan-1-yl)acetyl)-2-azabicyclo[3.1.0]hexane-3-carbonitrile; Saxagliptin API; Saxagliptin Onglyza BMS; Saxagliptin //BP; 2-Azabicyclo[3.1.0]hexane-3-carbonitrile,2-[(2S)-amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1S,3S,5S); Saxagliptin , SAXAGLIPTIN; BMS477118;SAXAGLIPTIN; (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadaMantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; Saxagliptin selective and reversible DPP4 inhibitor; (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-tricyclo[3.3.13,7]dec-1-yl)-1-oxoethyl]-2-azabicyclo-[3.1.0]hexane-3-carbonitrile; Saxagliptin-13C-d2 HCl; (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]decan-1-yl)acetyl]-2-azadicyclo[3.1.0]hexane-3-nitrile

物化性质

• 密度: 1.35
• 沸点: 548.7±35.0 °C at 760 mmHg
• 分子式: C₁₈H₂₅N₃O₂
• 分子量: 315.410
• 闪点: 285.6±25.9 °C
• 精确质量: 315.194672
• PSA: 90.35000
• LogP: -0.14
• 外观性状: 粉末
• 蒸汽压: 0.0±3.3 mmHg at 25°C
• 折射率: 1.640
• 储存条件: -20℃

生物活性

• 描述: Saxagliptin(BMS477118)是选择性可逆的DPP4抑制剂,IC50和Ki分别为26 nM和1.3 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 二肽基肽酶
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Tahrani AA, et al. Saxagliptin: a dipeptidyl peptidase-4 inhibitor in the treatment of type 2 diabetes mellitus By Dave, Darshan J. From Journal of Pharmacology and Pharmacotherapeutics (2011), 2(4), 230-235.

  [2]. Richter B, et al. Emerging role of dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes. Vasc Health Risk Manag. 2008;4(4):753-68.

  [3]. Deacon CF, et al. Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes. Adv Ther. 2009 May;26(5):488-99.

  [4]. Augeri DJ, et al. Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2005 Jul 28;48(15):5025-37.

安全

• 危害码 (欧洲): Xn
• 风险声明 (欧洲): 28-38-41-48
• 安全声明 (欧洲): 24/25-26-28-36/37/39
• 危险品运输编码: 3077
• 海关编码: 2933990090

海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%