834153-87-6

• 常用中文名：恶拉戈利
• 常用英文名：elagolix
• CAS号：834153-87-6
• 分子式：C₃₂H₃₀F₅N₃O₅
• 分子量：631.590
• 相关类别： 原料药 激素及调节内分泌功能类药 促性激素类药
• 发布时间：2018-07-08 11:23:38
• 更新时间：2026-07-16 20:17:50
• Elagolix是一种高度有效的, 选择性, 口服活性的, 短期的, 非肽类促性腺激素释放激素受体 (GnRH受体) 拮抗剂 (KD = 54 pM)。

名称

• 中文名: 噁拉戈利
• 英文名: Elagolix
• 中文别名: 噁拉戈利标准品4-R; 噁拉戈利相关杂质; 恶拉戈利,10 MM DMSO 溶液; 噁拉戈利 ELAGOLIX; 噁拉戈利钠Elagolix Sodium; (R)-4-((2-(5-(2-氟-3-甲氧苯基)-3-(2-氟-6-(三氟甲基)苯甲基)-4-甲基-2,6-二氧代-2,3-二氢嘧啶-1(6H) –基)-1-苯乙基)氨基)正丁酸钠,恶拉戈利; 恶拉戈利相关杂质; 拉戈利; 4-[[(1R)-2-[5-(2-氟-3-甲氧基苯基)-3-[[2-氟-6-(三氟甲基)苯基]甲基]-3,6-二氢-4-甲基-2,6-二氧代-1(2H)-嘧啶基]-1-苯乙基]氨基]丁酸; 4-[[(1R)-2-[5-(2-氟-3-甲氧基苯基)-3-[[2-氟-6-(三氟甲基)苯基]甲基]-4-甲基-2,6-二氧嘧啶-1-基-1-苯乙基]氨基]丁酸; 恶拉戈利钠N-1; F拉戈利; 艾拉戈克
• 英文别名: Elagolix-004-R; Tropicamide Impurity 35; (R)-Elagolix; Elagolix-d6; Butanoic acid, 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]amino]; 4-({(1R)-2-[5-(2-Fluoro-3-methoxyphenyl)-3-[2-fluoro-6-(trifluoromethyl)benzyl]-4-methyl-2,6-dioxo-3,6-dihydro-1(2H)-pyrimidinyl]-1-phenylethyl}amino)butanoic acid; Elagolix Sodium Monomer; 4-[[(1R)-2-[5-(2-Fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]amino]butanoic acid; 4-[[(1R)-2-[5-(2-FLUORO-3-METHOXYPHENYL)-3-[[2-FLUORO-6-(TRIFLUOROMETHYL)PHENYL]METHYL]-4-METHYL-2,6-DIOXOPYRIMIDIN-1-YL]-1-PHENYLETHYL]AMINO]BUTANOIC ACID; Seviram hydrochloride; (R)-Elagolix, 10 mM in DMSO; NBI 56418; NBI56418;NBI-56418; Elagolix sodium 4-[[(1R)-2-[5-(2-Fluoro-3-methoxyphenyl)-3-[[2-fluoro-6- (trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6- dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]amino]butanoic acid; 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]butanoic acid; ABT-620; elagolix //BP; (R)-4-((2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)-1-phenylethyl)amino)butanoic acid; Elagolix CAS; (R)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-[2-fluoro-6-(trifluoromethyl)benzyl]-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyric acid; Elagolix (NBI-56418); Elagoli

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 728.6±70.0 °C at 760 mmHg
• 分子式: C₃₂H₃₀F₅N₃O₅
• 分子量: 631.590
• 闪点: 394.5±35.7 °C
• 精确质量: 631.210571
• PSA: 102.56000
• LogP: 7.20
• 蒸汽压: 0.0±2.5 mmHg at 25°C
• 折射率: 1.567
• 储存条件: 2-8℃

生物活性

• 描述: Elagolix是一种高度有效的, 选择性, 口服活性的, 短期的, 非肽类促性腺激素释放激素受体 (GnRH受体) 拮抗剂 (KD = 54 pM)。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> GNRH受体
  研究领域 >> 癌症
• 参考文献:

  [1]. Carr B, et al. Elagolix, an oral GnRH antagonist, versus subcutaneous depot medroxyprogesterone acetate for the treatment of endometriosis: effects on bone mineral density. Reprod Sci. 2014 Nov;21(11):1341-1351.

合成路线

832720-84-0 ~91% 834153-87-6

文献：NEUROCRINE BIOSCIENCES, INC. Patent: WO2009/62087 A1, 2009 ; Location in patent: Page/Page column 17, 18 ; WO 2009/062087 A1

1092070-97-7 ~% 834153-87-6

文献：Journal of Medicinal Chemistry, , vol. 51, # 23 p. 7478 - 7485