A-867744

• 常用名: A-867744
• 英文名: A-867744
• CAS号: 1000279-69-5
• 分子量: 402.89400
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₉ClN₂O₃S
• 熔点: N/A
• 闪点: N/A

A-867744用途

A-867744是α7 nAChRs的阳性变构调节剂，在非洲爪蟾卵细胞中对人和鼠的α7受体ACh激发的电流IC50分别为0.98 和1.12 μM。

A-867744名称

• 中文名: A-867744
• 英文名: 4-[5-(4-chlorophenyl)-2-methyl-3-propanoylpyrrol-1-yl]benzenesulfonamide

A-867744生物活性

• 描述: A-867744是α7 nAChRs的阳性变构调节剂,在非洲爪蟾卵细胞中对人和鼠的α7受体ACh激发的电流IC50分别为0.98 和1.12 μM。
• 相关类别:
  信号通路 >> 自噬 >> 自噬
  信号通路 >> 跨膜转运 >> 胆碱受体
  信号通路 >> 神经信号通路 >> 胆碱受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Faghih R, et al. Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.J Med Chem. 2009 May 28;52(10):3377-84.

  [2]. Malysz J, et al. In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile.J Pharmacol Exp Ther. 2009 Jul;330(1):257-67. Epub 2009 Apr 23.

  [3]. Malysz J, et al. In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107.J Pharmacol Exp Ther. 2010 Sep 1;334(3):863-74. Epub 2010 May 26.

  [4]. Hu M, et al. Positive allosteric modulation of alpha7 neuronal nicotinic acetylcholine receptors: lack of cytotoxicity in PC12 cells and rat primary cortical neurons.Br J Pharmacol. 2009 Dec;158(8):1857-64.

  [5]. Ramin Faghih, et al. Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor J. Med. Chem., 2009, 52 (10), pp 3377-3384

A-867744物理化学性质

• 分子式: C₂₀H₁₉ClN₂O₃S
• 分子量: 402.89400
• 精确质量: 402.08000
• PSA: 90.54000
• LogP: 6.12730
• 储存条件: -20°C

A-867744靶点实验

查看更多实验

实验名称：Cognitive enhancing effect in scopolamine-induced NMRI mouse model of amnesia assesse... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4737282

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Confirmatory qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinas... 来源：NCGC External Id：IP6K1-f1-cherrypicks

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Lipophilicity, logP of compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL4737265

实验名称：Efflux ratio of apparent permeability in vinblastine-treated human Caco2 cells at 1 u... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4737256

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

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A-867744英文别名

• UNII-O6NW23A765
• CS-0271
• 4-(5-(4-Chlorophenyl)-2-methyl-3-propionylpyrrol-1-yl)benzenesulfonamide
• A-867744