Crolibulin

• 常用名: Crolibulin
• 英文名: Crolibulin
• CAS号: 1000852-17-4
• 分子量: 417.25700
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₁₇BrN₄O₃
• 熔点: N/A
• 闪点: N/A

Crolibulin用途

Crolibulin 是一种小分子微管蛋白聚合抑制剂。

Crolibulin名称

• 中文名: Crolibulin
• 英文名: (4R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile

Crolibulin生物活性

• 描述: Crolibulin 是一种小分子微管蛋白聚合抑制剂。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 微管/微管蛋白
  信号通路 >> 细胞骨架 >> 微管/微管蛋白
  研究领域 >> 癌症
• 靶点实验:

  tubulin polymerization[1]

• 参考文献:

  [1]. Kalmuk J, et al. Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer. Oncotarget. 2015 Sep 15;6(27):24376-92.

  [2]. Zhai X, et al. Discovery and Optimization of Novel 5-Indolyl-7-arylimidazo[1,2-a]pyridine-8-carbonitrile Derivatives as Potent Antitubulin Agents Targeting Colchicine-binding Site. Sci Rep. 2017 Feb 27;7:43398.

Crolibulin物理化学性质

• 分子式: C₁₈H₁₇BrN₄O₃
• 分子量: 417.25700
• 精确质量: 416.04800
• PSA: 129.54000
• LogP: 4.71158
• InChIKey: JXONINOYTKKXQQ-CQSZACIVSA-N
• SMILES: COc1cc(C2C(C#N)=C(N)Oc3c2ccc(N)c3N)cc(Br)c1OC
• 储存条件: 2-8℃

Crolibulin靶点实验

查看更多实验

实验名称：Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：SMMC-7721 External Id：CHEMBL4147473

实验名称：Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL4147469

实验名称：Antiproliferative activity against human H460 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：NCI-H460 External Id：CHEMBL4147470

实验名称：Antiproliferative activity against human A549 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：A549 External Id：CHEMBL4147471

实验名称：Antiproliferative activity against human MKN45 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：MKN-45 External Id：CHEMBL4147472

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Crolibulin英文别名

• Crolibulin
• (R)-2,7,8-triamino-3-cyano-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene
• Crolibulin [USAN:INN]
• Crolibulin [USAN]
• R(-)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromene