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ISPA-28

ISPA-28结构式
ISPA-28结构式
品牌特惠专场
常用名 ISPA-28 英文名 ISPA-28
CAS号 1006335-39-2 分子量 408.454
密度 1.4±0.1 g/cm3 沸点 N/A
分子式 C21H24N6O3 熔点 N/A
MSDS 美版 闪点 N/A

An epigenetic antimalarial resistance mechanism involving parasite genes linked to nutrient uptake.

J. Biol. Chem. 288(27) , 19429-40, (2013)

Acquired antimalarial drug resistance produces treatment failures and has led to periods of global disease resurgence. In Plasmodium falciparum, resistance is known to arise through genome-level changes such as mutations and gene duplications. We now report a...

Malaria parasite mutants with altered erythrocyte permeability: a new drug resistance mechanism and important molecular tool.

Future Microbiol. 5(1) , 81-97, (2010)

Erythrocytes infected with plasmodia, including those that cause human malaria, have increased permeability to a diverse collection of organic and inorganic solutes. While these increases have been known for decades, their mechanistic basis was unclear until ...