p38 MAPK-IN-1

• 常用名: p38 MAPK-IN-1
• 英文名: p38 MAPK-IN-1
• CAS号: 1006378-90-0
• 分子量: 349.35
• 密度: 1.3±0.1 g/cm3
• 沸点: 527.0±50.0 °C at 760 mmHg
• 分子式: C₂₁H₁₅F₂N₂O
• 熔点: N/A
• 闪点: 272.5±30.1 °C

p38 MAPK-IN-1用途

p38 MAPK-IN-1是p38 MAPK新型高效选择性抑制剂, IC50值68nM。

p38 MAPK-IN-1名称

• 中文名: p38 MAPK-IN-1
• 英文名: p38 MAPK-IN-1

p38 MAPK-IN-1生物活性

• 描述: p38 MAPK-IN-1是p38 MAPK新型高效选择性抑制剂, IC50值68nM。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> p38 MAPK
  研究领域 >> 癌症
• 参考文献:

  [1]. Lumeras W, et al. 1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem. 2011 Nov 24;54(22):7899-910.

p38 MAPK-IN-1物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 527.0±50.0 °C at 760 mmHg
• 分子式: C₂₁H₁₅F₂N₂O
• 分子量: 349.35
• 闪点: 272.5±30.1 °C
• LogP: 2.46
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.622
• 储存条件: 2-8℃

p38 MAPK-IN-1靶点实验

查看更多实验

实验名称：Half life in Wistar rat at 1 mg/kg, iv by UPLC-MS/MS analysis 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1921393

实验名称：AUC (0 to 6 hrs) in Wistar rat at 10 mg/kg, po by UPLC-MS/MS analysis 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1921392

实验名称：Volume of distribution at steady state in Wistar rat at 1 mg/kg, iv by UPLC-MS/MS ana... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1921395

实验名称：Clearance in Wistar rat at 1 mg/kg, iv by UPLC-MS/MS analysis 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1921394

实验名称：Antiinflammatory activity in po dosed rat assessed as inhibition of LPS-induced rise ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1921397

实验名称：Bioavailability in Wistar rat at 10 mg/kg, po and at 1 mg/kg, iv measured up to 6 hrs 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1921396

实验名称：Antiarthritic activity in po dosed adjuvant-induced Wistar rat arthritis model assess... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1921398

实验名称：Inhibition of CYP2D6 in human liver microsomes at 10 uM after 30 mins by UPLC-MS/MS a... 来源：ChEMBL 靶标：Cytochrome P450 2D6 External Id：CHEMBL1921385

实验名称：Inhibition of CYP3A4 in human liver microsomes at 10 uM after 10 mins by UPLC-MS/MS a... 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL1921384

实验名称：Cytotoxicity against CHO cells at 200 uM 来源：ChEMBL 靶标：CHO External Id：CHEMBL1921387

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p38 MAPK-IN-1英文别名

• 1,7-Naphthyridine, 4-(2,4-difluorophenyl)-8-(2-methylphenyl)-, 7-oxide
• 4-(2,4-Difluorophenyl)-8-(2-methylphenyl)-1,7-naphthyridine 7-oxide