Formamide,N-[(1E)-2-(2,5-dihydroxyphenyl)ethenyl]

• 常用名: Formamide,N-[(1E)-2-(2,5-dihydroxyphenyl)ethenyl]
• 英文名: Formamide,N-[(1E)-2-(2,5-dihydroxyphenyl)ethenyl]
• CAS号: 100827-28-9
• 分子量: 179.17
• 密度: 1.343g/cm3
• 沸点: 517.5ºC at 760mmHg
• 分子式: C₉H₉NO₃
• 熔点: N/A
• 闪点: 266.8ºC

用途

Erbstatin是一种EGFR激酶抑制剂,具有抗肿瘤作用[1][2]。

名称

• 英文名: N-[(E)-2-(2,5-dihydroxyphenyl)ethenyl]formamide

生物活性

• 描述: Erbstatin是一种EGFR激酶抑制剂,具有抗肿瘤作用[1][2]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> EGFR
  信号通路 >> 蛋白酪氨酸激酶 >> EGFR
• 体外研究: Erbstatin公司不抑制表皮生长因子与其受体的结合,但是会抑制表皮生长因子受体复合物的内吞作用,而且该化合物不会抑制A431细胞中表皮生长因子刺激的磷脂酰肌醇代谢[2] Erbstatin公司引起人小细胞肺癌(SCLC)细胞形态学凋亡和脱氧核糖核酸断裂[3]
• 参考文献:

  [1]. Shigeki Kobayashi, et al. Diastereomer-specific effects of double-stranded peptides conjugated with -L-Tyr-L-Phe- or -L-Tyr-D-Phe- residues on tyrosine phosphorylation and inhibition of src(ts)NRK, A431, MCF-7, and DU145 cell growth. Chem Pharm Bull (Tokyo). 2007 Nov;55(11):1585-92.

  [2]. M Toi, et al. Antineoplastic effect of erbstatin on human mammary and esophageal tumors in athymic nude mice. Eur J Cancer. 1990;26(6):722-4.

  [3]. S Simizu, et al. Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells. Cancer Res. 1996 Nov 1;56(21):4978-82.

物理化学性质

• 密度: 1.343g/cm3
• 沸点: 517.5ºC at 760mmHg
• 分子式: C₉H₉NO₃
• 分子量: 179.17
• 闪点: 266.8ºC
• 精确质量: 179.05800
• PSA: 69.56000
• LogP: 1.84130
• InChIKey: SIHZWGODIRRSRA-ONEGZZNKSA-N
• SMILES: O=CNC=Cc1cc(O)ccc1O
• 蒸汽压: 2.48E-11mmHg at 25°C
• 折射率: 1.667

毒性和生态

靶点实验

查看更多实验

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Identifying Sarm1 TIR NADase inhibitors through high throughput HPLC assay 来源：24386 靶标：N/A External Id：Sarm1 TIR NADase inhibitors

实验名称：Inhibition of Epidermal growth factor receptor 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL674706

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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英文别名

• N-[2-(2,5-dihydroxyphenyl)ethenyl]formamide
• FORMAMIDE,N-(2-(2,5-DIHYDROXYPHENYL)ETHENYL)-,(E)
• (E)-N-(2-(2,5-Dihydroxyphenyl)ethenyl)formamide
• (2-formamidovinyl)-2,5-dihydroxybenzene
• Erbstatin