乙溴替丁

• 常用名: 乙溴替丁
• 英文名: Ebrotidine
• CAS号: 100981-43-9
• 分子量: 477.423
• 密度: 1.7±0.1 g/cm3
• 沸点: 672.3±65.0 °C at 760 mmHg
• 分子式: C₁₄H₁₇BrN₆O₂S₃
• 熔点: N/A
• 闪点: 360.4±34.3 °C

乙溴替丁用途

Ebrotidine(FI 3542)是竞争性H2受体拮抗剂，Ki为127.5nM，具有抗分泌活性，可用于胃保护。

乙溴替丁名称

• 中文名: 乙溴替丁
• 英文名: N-(4-bromophenyl)sulfonyl-N'-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide

乙溴替丁生物活性

• 描述: Ebrotidine(FI 3542)是竞争性H2受体拮抗剂,Ki为127.5nM,具有抗分泌活性,可用于胃保护。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 组胺受体
  信号通路 >> 免疫及炎症 >> 组胺受体
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Agut J, Sánchez JC, Sacristán A, Action of ebrotidine, ranitidine and cimetidine on the specific binding to histamine H1- and H2-receptors. Arzneimittelforschung. 1997 Apr;47(4A):447-9.

  [2]. Palop D, Agut J, Márquez M, Histamine H2-receptor antagonist action of ebrotidine. Effects on gastric acid secretion, gastrin levels and NSAID-induced gastrotoxicity in the rat. Arzneimittelforschung. 1997 Apr;47(4A):439-46.

  [3]. Konturek SJ, Kwiecien N, Sito E, Effects of ebrotidine on aspirin-induced gastric mucosal damage and blood flow in humans. Scand J Gastroenterol. 1993 Dec;28(12):1047-50.

  [4]. Piotrowski J, Yamaki K, Morita M, Ebrotidine--a new H2-receptor antagonist with mucosal strengthening activity. Biochem Int. 1992 Mar;26(4):659-67.

乙溴替丁物理化学性质

• 密度: 1.7±0.1 g/cm3
• 沸点: 672.3±65.0 °C at 760 mmHg
• 分子式: C₁₄H₁₇BrN₆O₂S₃
• 分子量: 477.423
• 闪点: 360.4±34.3 °C
• 精确质量: 475.975830
• PSA: 195.24000
• LogP: 3.37
• InChIKey: ZQHFZHPUZXNPMF-UHFFFAOYSA-N
• SMILES: NC(N)=Nc1nc(CSCCN=CNS(=O)(=O)c2ccc(Br)cc2)cs1
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.740
• 储存条件: 2-8℃

乙溴替丁毒性和生态

乙溴替丁安全信息

• 海关编码: 2942000000

乙溴替丁海关

• 海关编码: 2942000000

乙溴替丁靶点实验

查看更多实验

实验名称：Drug Induced Liver Injury Prediction System (DILIps) validation dataset; compound DIL... 来源：ChEMBL 靶标：Hepatotoxicity External Id：CHEMBL1909321

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Choleostatic liver toxicity, either proven histopathologically or where the ratio of ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137727

实验名称：Severe hepatitis, defined as possibly life-threatening liver failure or through clini... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137728

实验名称：Chronic liver disease either proven histopathologically, or through a chonic elevatio... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137729

实验名称：Cirrhosis, proven histopathologically. Value is number of references indexed. [column... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137730

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Granulomatous liver disease, proven histopathologically. Value is number of reference... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3137731

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive dise... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137732

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乙溴替丁英文别名

• 4-Bromo-N-[(E)-({2-[({2-[(diaminomethylene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]ethyl}imino)methyl]benzenesulfonamide
• Ebrotidina [Spanish]
• Ebrotidina
• 4-bromo-N-{(E)-[(2-{[(2-carbamimidamido-1,3-thiazol-4-yl)methyl]sulfanyl}ethyl)amino]methylidene}benzenesulfonamide
• Ebrotidine
• Benzenesulfonamide,N-(((2-(((2-((aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)ethyl)amino)methylene)-4-bromo-,(E)
• n-p-bromobenzenesulfonyl-n'-[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]formamidine
• Ebrotidinum [Latin]
• Ebrotiding
• N-[[[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromobenzenesulfonamide
• FI-3542
• p-Bromo-N-[[[2-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]ethyl]amino]methylene]benzenesulfonamide
• Ulsanic
• Ebrotidinum