R-9-氟-2,3-二氢-3-甲基-10-(4-甲基-1-哌嗪基)-7-氧代-7H-吡啶并[1,2,3-DE]-[1,4]苯并噁嗪-6-羧酸

• 常用名: R-9-氟-2,3-二氢-3-甲基-10-(4-甲基-1-哌嗪基)-7-氧代-7H-吡啶并[1,2,3-DE]-[1,4]苯并噁嗪-6-羧酸
• 英文名: D-Ofloxacin
• CAS号: 100986-86-5
• 分子量: 361.367
• 密度: 1.5±0.1 g/cm3
• 沸点: 571.5±50.0 °C at 760 mmHg
• 分子式: C₁₈H₂₀FN₃O₄
• 熔点: N/A
• 闪点: 299.4±30.1 °C

用途

(R)-Ofloxacin (Dextrofloxacin) 是一种抗生素,可用于治疗许多细菌感染。具有抗菌活性。

名称

• 中文名: R-9-氟-2,3-二氢-3-甲基-10-(4-甲基-1-哌嗪基)-7-氧代-7H-吡啶并[1,2,3-DE]-[1,4]苯并噁嗪-6-羧酸
• 英文名: D-Ofloxacin

生物活性

• 描述: (R)-Ofloxacin (Dextrofloxacin) 是一种抗生素,可用于治疗许多细菌感染。具有抗菌活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Nahla N. Salama, et al. Thin-Layer Chromatographic Enantioseparation of Ofloxacin and Zopiclone using Hydroxy-Propyl-BetaCyclodextrin as Chiral Selector and Thermodynamic Studies of Complexation. Journal of Planar Chromatography. 27 (2014) 3, 166-173.

物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 571.5±50.0 °C at 760 mmHg
• 分子式: C₁₈H₂₀FN₃O₄
• 分子量: 361.367
• 闪点: 299.4±30.1 °C
• 精确质量: 361.143799
• PSA: 75.01000
• LogP: 0.84
• InChIKey: GSDSWSVVBLHKDQ-SNVBAGLBSA-N
• SMILES: CC1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.670

安全信息

• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2934999090

海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

靶点实验

查看更多实验

实验名称：Antimicrobial activity against the Escherichia coli JUHL by 2-fold agar dilution meth... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL676409

实验名称：Antimicrobial activity against the klebsiella pneumoniae 8045 by 2-fold agar dilution... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL700143

实验名称：Antimicrobial activity against the Staphylococcus epidermis 3519 by 2-fold agar dilut... 来源：ChEMBL 靶标：Staphylococcus epidermidis External Id：CHEMBL805062

实验名称：Antimicrobial activity against the streptococcus bovis A 5169 by 2-fold agar dilution... 来源：ChEMBL 靶标：Streptococcus equinus External Id：CHEMBL858078

实验名称：Antimicrobial activity against the Staphylococcus aureus ATCC 6538 P by 2-fold agar d... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL805061

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

实验名称：Antimicrobial activity against the Staphylococcus aureus 45 by 2-fold agar dilution m... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL805060

实验名称：Antimicrobial activity against the acinetobacter sp. CMX 669 by 2-fold agar dilution ... 来源：ChEMBL 靶标：Acinetobacter External Id：CHEMBL636123

实验名称：S16 Schwann cell viability assay (CellTiter-Glo assay) 来源：NCGC 靶标：N/A External Id：cmt-p4-fda-celltiter_regid

实验名称：Biochemical firefly luciferase enzyme assay for NPC 来源：NCGC 靶标：Luciferase [Photinus pyralis] External Id：adst-fluc-km-fda-o1_regid

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英文别名

• DR 3354
• (R)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid
• (R)-Ofloxacin
• (3R)-9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
• D-ofloaxcin
• (+)-Ofloxacin
• DEXTROFLOXACINE
• d-isomer of ofloxacin