100986-86-5

• 常用中文名：R-9-氟-2,3-二氢-3-甲基-10-(4-甲基-1-哌嗪基)-7-氧代-7H-吡啶并[1,2,3-DE]-[1,4]苯并噁嗪-6-羧酸
• 常用英文名：D-Ofloxacin
• CAS号：100986-86-5
• 分子式：C₁₈H₂₀FN₃O₄
• 分子量：361.367
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2016-01-24 21:33:41
• 更新时间：2026-07-06 18:17:30
• (R)-Ofloxacin (Dextrofloxacin) 是一种抗生素,可用于治疗许多细菌感染。具有抗菌活性。

名称

• 中文名: R-9-氟-2,3-二氢-3-甲基-10-(4-甲基-1-哌嗪基)-7-氧代-7H-吡啶并[1,2,3-DE]-[1,4]苯并噁嗪-6-羧酸
• 英文名: D-Ofloxacin
• 中文别名: (R)-氧氟沙星; 左氧氟沙星杂质 2; 右 杂质; 左氧氟沙星杂质6 (左氧氟沙星杂质A)(R异构体); 左氧氟沙星 A; 氧氟沙星杂质2((R)-氧氟沙星); 左氧氟沙星杂质Ⅰ右氧氟沙星（+）-（R）-3-甲基-9-氟-2,3-二氢-10-（4-甲基-1-哌嗪基）-7-氧代-7H-吡啶并[1,2,3-de]-[1,4]苯并噁嗪-6-羧酸; 左氧氟沙星R-异构体; 右氧氟沙星对照品; R-氧氟沙星 标准品; (R)-9-氟-3-甲基-10-(4-甲基哌嗪-1-基)-7-氧代-2,3-二氢-7H-[1,4]恶嗪并[2,3,4-IJ]喹啉-6-羧酸; 杂质G(右氧氟沙星) 100-5; 氧氟沙星R-异构体; 左氧氟沙星杂质E; 右 杂质(R)-OFLOXACIN; 右氧氟沙星杂质A; 右氧沙星; D-氧氟沙星; 左氧氟沙星BP杂质A; 左氧氟沙星杂质A; 左氧氟沙星杂质Ⅰ右氧氟沙星(+)-(R)-3-甲基-9-氟-2,3-二氢-10-(4-甲基-1-哌嗪基)-7-氧代-7H-吡啶并[1,2,3-DE]-[1,4]苯并噁嗪-6-羧酸; 左氧氟沙星R-异构体(左氧氟沙星杂质A); 盐酸左氧氟沙星杂质Ⅰ(右氧氟沙星)(+)-(R)-3-甲基-9-氟-2,3-二氢-10-(4-甲基-1-哌嗪基)-7-氧代-7H-吡啶并[1,2,3-DE]-[1,4]苯并噁嗪-6-羧酸
• 英文别名: R-9-fluoro-2, 3-dihydro-3-Methyl-10-(4-Methyl-1-piperazinyl)-7-oxo-7h-pyrido[1,2,3-de]-1,4-benzoxazine-6-cboxylic acid; Levofloxacin Impurity L; Levofloxacin Impurity 6（R-Isomer）; Levofloxacin ImpurityⅠ:(3R)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-cboxylic Acid; DS-4632; D-Isomer of ofloxacin; Ofloxacin Impurity 2((R)-Ofloxacin); (R)-Ofloxacin,e.e; D-OFLOXACIN; Levofloxacin BP Impurity A; (2R)-7-Fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.0,13]trideca-5,6,8,11-tetraene-11-cboxylic acid; Aids-002308; Levofloxacin impurity 9/Ofloxacin R-Isomer/(R)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-cboxylic acid; R-Ofloxacin ((R)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de; (3R)-9-Fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; R-Ofloxacin; Levofloxacin (R)-Ofloxacin; Levofloacin Impurity E; [3R,(+)]-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-cboxylic acid; DEXTROFLOXACINE; Aids002308; (R)-9-fluoro-3-methyl; 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-cboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (3R)- (9CI); 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-cboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (R); Levofloxacin-5; d-isomer of ofloxacin; Ofloxacin R-Isomer; R-Ofloxacin (25 mg) ((R)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-cboxylic acid); DR 3354; (R)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2; (R)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-cboxylic acid; (R)-Ofloxacin; Levofloxacin Impurity A（Levofloxacin R-Isomer）; d-Levofloxacin; D-ofloaxcin; (3R)-9-Fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-pyrido[1, 2,3-de][1,4]benzoxazine-6-cboxylic acid; 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-cboxylic acid, 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-, (3R); (R)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; Levofloxacin Impurity A; Levofloxacin Hydrochloride ImpurityⅠ: (Dextrofloxacin)(R)-Levofloxacin; Levofloxacin R-Isomer（Levofloxacin Impurity A）; Levofloxacin R-IsoMer; (+)-Ofloxacin; Levofloxacin Impurity 6 (Levofloxacin Impurity A)(R-Isomer)

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 571.5±50.0 °C at 760 mmHg
• 分子式: C₁₈H₂₀FN₃O₄
• 分子量: 361.367
• 闪点: 299.4±30.1 °C
• 精确质量: 361.143799
• PSA: 75.01000
• LogP: 0.84
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.670

生物活性

• 描述: (R)-Ofloxacin (Dextrofloxacin) 是一种抗生素,可用于治疗许多细菌感染。具有抗菌活性。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Nahla N. Salama, et al. Thin-Layer Chromatographic Enantioseparation of Ofloxacin and Zopiclone using Hydroxy-Propyl-BetaCyclodextrin as Chiral Selector and Thermodynamic Studies of Complexation. Journal of Planar Chromatography. 27 (2014) 3, 166-173.

安全

• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2934999090

合成路线

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海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%