Tenovin-3

• 常用名: Tenovin-3
• 英文名: Tenovin-3
• CAS号: 1011301-27-1
• 分子量: 327.444
• 密度: 1.2±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₈H₂₁N₃OS
• 熔点: N/A
• 闪点: N/A

Tenovin-3用途

Tenovin-3可增加p53水平 (10μM 作用于MCF-7细胞6小时后测定) 。

Tenovin-3名称

• 中文名: N-[[(4-氨基苯基)氨基]硫代甲酰基]-4-(叔丁基)苯甲酰胺
• 英文名: N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide

Tenovin-3生物活性

• 描述: Tenovin-3可增加p53水平 (10μM 作用于MCF-7细胞6小时后测定) 。
• 相关类别:
  信号通路 >> 细胞凋亡 >> MDM-2/p53
  研究领域 >> 癌症
• 参考文献:

  [1]. Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63.

Tenovin-3物理化学性质

• 密度: 1.2±0.1 g/cm3
• 分子式: C₁₈H₂₁N₃OS
• 分子量: 327.444
• 精确质量: 327.140533
• PSA: 109.77000
• LogP: 2.82
• InChIKey: NLAXTZPUTNGRDU-UHFFFAOYSA-N
• SMILES: CC(C)(C)c1ccc(C(=O)NC(=S)Nc2ccc(N)cc2)cc1
• 外观性状: yellow solid
• 折射率: 1.662
• 储存条件: -20℃

Tenovin-3靶点实验

查看更多实验

实验名称：Half life in mouse liver microsomes preincubated for 5 mins followed by NADPH additio... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5516441

实验名称：Anti-influenza activity against Influenza A virus H3N2 infected in HEK293T cells asse... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL5516440

实验名称：Anti-influenza activity against Influenza B virus Victoria/2/87 infected in HEK293T c... 来源：ChEMBL 靶标：Influenza B virus External Id：CHEMBL5516439

实验名称：Anti-influenza activity against Influenza B virus Yamagata/16/88 infected in HEK293T ... 来源：ChEMBL 靶标：Influenza B virus External Id：CHEMBL5516438

实验名称：Selectivity index, ratio of CC50 for cytotoxicity against human HEK293T cells to EC50... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5516437

实验名称：Antiviral activity against Influenza A virus H1N1 (A/Puerto Rico/8/34) infected in MD... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL5627538

实验名称：Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incu... 来源：ChEMBL 靶标：HEK-293T External Id：CHEMBL5516436

实验名称：Antiviral activity against Vaccinia virus 来源：ChEMBL 靶标：Vaccinia virus External Id：CHEMBL2044326

实验名称：Cytotoxicity against MDCK cells by CCK-8 assay 来源：ChEMBL 靶标：MDCK External Id：CHEMBL5627539

实验名称：Anti-influenza activity against Influenza A virus A/WSN/33(H1N1) infected in HEK293T ... 来源：ChEMBL 靶标：Influenza A virus External Id：CHEMBL5516435

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Tenovin-3英文别名

• N-[(4-Aminophenyl)carbamothioyl]-4-(2-methyl-2-propanyl)benzamide
• QC-514
• 1-(4-amino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea
• N-[(4-aminophenyl)-carbamothioyl]-4-tert-butyl-benzamide
• Tenovin-3