Carbonic anhydrase inhibitor 6

• 常用名: Carbonic anhydrase inhibitor 6
• 英文名: Carbonic anhydrase inhibitor 6
• CAS号: 1013213-84-7
• 分子量: 491.56
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₅N₃O₅S
• 熔点: N/A
• 闪点: N/A

Carbonic anhydrase inhibitor 6用途

碳酸酐酶抑制剂6(化合物9b)是人体碳酸酐酶(hCA)的有效抑制剂,hCA IX、hCA II、hCA XII和hCA I的Kis分别为9.7 nM、35.2 nM、88.5 nM和91.8 nM【1】。

Carbonic anhydrase inhibitor 6名称

• 英文名: Carbonic anhydrase inhibitor 6

Carbonic anhydrase inhibitor 6生物活性

• 描述: 碳酸酐酶抑制剂6(化合物9b)是人体碳酸酐酶(hCA)的有效抑制剂,hCA IX、hCA II、hCA XII和hCA I的Kis分别为9.7 nM、35.2 nM、88.5 nM和91.8 nM【1】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 碳酸酐酶
• 参考文献:

  [1]. Swain B, et, al. Exploration of 2-phenylquinoline-4-carboxamide linked benzene sulfonamide derivatives as isoform selective inhibitors of transmembrane human carbonic anhydrases. Eur J Med Chem. 2022 Apr 15;234:114247.

Carbonic anhydrase inhibitor 6物理化学性质

• 分子式: C₂₆H₂₅N₃O₅S
• 分子量: 491.56
• InChIKey: HLSPYEFIWCWUBB-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2cc(C(=O)NCCc3ccc(S(N)(=O)=O)cc3)c3ccccc3n2)cc1OC

Carbonic anhydrase inhibitor 6靶点实验

查看更多实验

实验名称：Selectivity ratio of Ki for inhibition of human recombinant carbonic anhydrase 1 to K... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5135580

实验名称：Selectivity ratio of Ki for inhibition of human recombinant carbonic anhydrase 2 to K... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5135581

实验名称：Inhibition of human recombinant carbonic anhydrase 9 assessed as inhibition constant ... 来源：ChEMBL 靶标：Carbonic anhydrase 9 External Id：CHEMBL5135576

实验名称：Inhibition of human recombinant carbonic anhydrase 12 assessed as inhibition constant... 来源：ChEMBL 靶标：Carbonic anhydrase 12 External Id：CHEMBL5135577

实验名称：Selectivity ratio of Ki for inhibition of human recombinant carbonic anhydrase 1 to K... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5135578

实验名称：Selectivity ratio of Ki for inhibition of human recombinant carbonic anhydrase 2 to K... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5135579

实验名称：Inhibition of human recombinant carbonic anhydrase 1 assessed as inhibition constant ... 来源：ChEMBL 靶标：Carbonic anhydrase 1 External Id：CHEMBL5135574

实验名称：Inhibition of human recombinant carbonic anhydrase 2 assessed as inhibition constant ... 来源：ChEMBL 靶标：Carbonic anhydrase 2 External Id：CHEMBL5135575

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