mAChR antagonist 1

• 常用名: mAChR antagonist 1
• 英文名: mAChR antagonist 1
• CAS号: 101491-79-6
• 分子量: 310.39000
• 密度: 1.18g/cm3
• 沸点: 437ºC at 760 mmHg
• 分子式: C₁₉H₂₂N₂O₂
• 熔点: N/A
• 闪点: 218.1ºC

mAChR antagonist 1用途

mAChRagonist 1 (compound 4a) 是一种 mAChR 拮抗剂,对于 M1、M3、M4 和 M5 亚型的 Ki 值分别为 255 nM、121 nM、158 nM 和 255 nM。

mAChR antagonist 1名称

• 英文名: (1-methylpiperidin-4-yl) N,N-diphenylcarbamate

mAChR antagonist 1生物活性

• 描述: mAChRagonist 1 (compound 4a) 是一种 mAChR 拮抗剂,对于 M1、M3、M4 和 M5 亚型的 Ki 值分别为 255 nM、121 nM、158 nM 和 255 nM。
• 相关类别:
  信号通路 >> 神经信号通路 >> mAChR
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  研究领域 >> 神经疾病
• 靶点实验:

  mAChR1:255 nM (Ki)

  mAChR3:121 nM (Ki)

  mAChR4:158 nM (Ki)

  mAChR5:255 nM (Ki)

  mAChR2:>1000 nM (Ki)

• 参考文献:

  [1]. Marlon Millard, et al. Design, synthesis and preclinical evaluation of muscarine receptor antagonists via a scaffold-hopping approach. Eur J Med Chem. 2023 Oct 21:262:115891.

mAChR antagonist 1物理化学性质

• 密度: 1.18g/cm3
• 沸点: 437ºC at 760 mmHg
• 分子式: C₁₉H₂₂N₂O₂
• 分子量: 310.39000
• 闪点: 218.1ºC
• 精确质量: 310.16800
• PSA: 32.78000
• LogP: 3.99340
• InChIKey: RQDLDNLBJUDOFV-UHFFFAOYSA-N
• SMILES: CN1CCC(OC(=O)N(c2ccccc2)c2ccccc2)CC1
• 蒸汽压: 7.74E-08mmHg at 25°C
• 折射率: 1.613

mAChR antagonist 1靶点实验

查看更多实验

实验名称：Antagonist activity at human muscarinic M1 receptor expressed in CHO-K1 cell membrane... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M1 External Id：CHEMBL5638037

实验名称：Agonist activity at human muscarinic M1 receptor expressed in CHO-K1 cell membrane up... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M1 External Id：CHEMBL5638038

实验名称：Lipophilicity, log P of compound at pH 7.4 by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5638022

实验名称：Cytotoxicity against CHO-K1 cells expressing human muscarinic receptor M1 incubated f... 来源：ChEMBL 靶标：CHO-K1 External Id：CHEMBL5638023

实验名称：Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO-K1 cell me... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M1 External Id：CHEMBL5638024

实验名称：Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHO-K1 cell me... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M2 External Id：CHEMBL5638025

实验名称：Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHO-K1 cell me... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M3 External Id：CHEMBL5638026

实验名称：Displacement of [3H]NMS from human muscarinic M4 receptor expressed in CHO-K1 cell me... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M4 External Id：CHEMBL5638027

实验名称：Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO-K1 cell me... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M5 External Id：CHEMBL5638028

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mAChR antagonist 1英文别名

• 1-Methyl-4-piperidyl diphenylcarbamate
• 1-methylpiperidin-4-yl diphenylcarbamate
• CARBAMIC ACID,DIPHENYL-,1-METHYL-4-PIPERIDYL ESTER