MLS-573151

• 常用名: MLS-573151
• 英文名: MLS-573151
• CAS号: 10179-57-4
• 分子量: 377.460
• 密度: 1.3±0.1 g/cm3
• 沸点: 596.3±60.0 °C at 760 mmHg
• 分子式: C₂₁H₁₉N₃O₂S
• 熔点: N/A
• 闪点: 314.5±32.9 °C

MLS-573151用途

MLS-573151 (MLS000573151) 是一种选择性 GTPase Cdc42 的抑制剂,EC50 为 2 μM。MLS-573151 对其他 GTPases 家族成员无效,例如 Rab2,Rab7,H-Ras,Rac1,Rac 2 和 RhoA 野生型。MLS-573151 通过阻止 GTP 与 Cdc42 的结合来发挥作用。

MLS-573151名称

• 中文名: 4-(3,5-二苯基-4,5-二氢-1H-吡唑-1-基)苯磺酰胺
• 英文名: 4-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

MLS-573151生物活性

• 描述: MLS-573151 (MLS000573151) 是一种选择性 GTPase Cdc42 的抑制剂,EC50 为 2 μM。MLS-573151 对其他 GTPases 家族成员无效,例如 Rab2,Rab7,H-Ras,Rac1,Rac 2 和 RhoA 野生型。MLS-573151 通过阻止 GTP 与 Cdc42 的结合来发挥作用。
• 相关类别:
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 拉斯
• 体外研究: 用MLS-573151(50%)处理粒细胞后,血细胞内吞噬小球或细菌的荧光强度显著降低,作为吞噬效率的指标μ米；与对照组比较。MLS-573151能有效抑制粒细胞的吞噬能力[1]。
• 参考文献:

  [1]. Zurab Surviladze, et al. Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay. J Biomol Screen. 2010 Jan;15(1):10-20.

  [2]. Fan Mao, et al. Transcriptomic Evidence Reveals the Molecular Basis for Functional Differentiation of Hemocytes in a Marine Invertebrate, Crassostrea gigas. Front Immunol. 2020 May 27;11:911.

MLS-573151物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 596.3±60.0 °C at 760 mmHg
• 分子式: C₂₁H₁₉N₃O₂S
• 分子量: 377.460
• 闪点: 314.5±32.9 °C
• 精确质量: 377.119812
• PSA: 84.14000
• LogP: 1.90
• InChIKey: OPPCVEVPKHRJNY-UHFFFAOYSA-N
• SMILES: NS(=O)(=O)c1ccc(N2N=C(c3ccccc3)CC2c2ccccc2)cc1
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.669
• 储存条件: -20°C，干燥，密封

MLS-573151靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

共155条，当前第1页，共16页

1

2

3

4

5

MLS-573151英文别名

• 4-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
• 1-<4-Pyrrolidinomethyl-phenyl>-2-phenyl-6-methoxy-3,4-dihydronaphthalin-hydrochlorid
• MLS-573151