CARM1-IN-1

• 常用名: CARM1-IN-1
• 英文名: CARM1-IN-1
• CAS号: 1020399-49-8
• 分子量: 555.25800
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₁Br₂NO₃
• 熔点: N/A
• 闪点: N/A

CARM1-IN-1用途

CARM1-IN-1是CARM1高效选择性抑制剂，IC50值为8.6uM，对PRMT1和SET7抑制活性很抵。

CARM1-IN-1名称

• 中文名: CARM1-IN-1
• 英文名: 3,5-bis(3-bromo-4-hydroxybenzylidene)-1-benzylpiperidin-4-one

CARM1-IN-1生物活性

• 描述: CARM1-IN-1是CARM1高效选择性抑制剂,IC50值为8.6uM,对PRMT1和SET7抑制活性很抵。
• 相关类别:
  信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶
  研究领域 >> 癌症
• 参考文献:

  [1]. Cheng D, et al. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32.

CARM1-IN-1物理化学性质

• 分子式: C₂₆H₂₁Br₂NO₃
• 分子量: 555.25800
• 精确质量: 552.98900
• PSA: 60.77000
• LogP: 6.11260
• InChIKey: KNMFTTWVELIVCC-CLVAPQHMSA-N
• SMILES: O=C1C(=Cc2ccc(O)c(Br)c2)CN(Cc2ccccc2)CC1=Cc1ccc(O)c(Br)c1
• 储存条件: 2-8℃

CARM1-IN-1靶点实验

查看更多实验

实验名称：Antiplasmodial activity against asynchronous form of Plasmodium falciparum 3D7 infect... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL4327288

实验名称：Antiplasmodial activity against asynchronous form of Plasmodium falciparum 3D7 infect... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL4327287

实验名称：Inhibition of Aspergillus nidulans RmtA at 77 uM 来源：ChEMBL 靶标：RmtA External Id：CHEMBL925751

实验名称：Inhibition of SET7-mediated methylation of histone H3 after 90 mins by scintillation ... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase SETD7 External Id：CHEMBL1804746

实验名称：Inhibition of human recombinant SET7 assessed as histone H3 protein methylation at 10... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase SETD7 External Id：CHEMBL925759

实验名称：Inhibition of PRMT1-mediated methylation of NPL3 after 90 mins by scintillation count... 来源：ChEMBL 靶标：Protein arginine N-methyltransferase 1 External Id：CHEMBL1804745

实验名称：Inhibition of histone H3K4 methylation in human U937 cells at 50 uM after 24 hrs 来源：ChEMBL 靶标：U-937 External Id：CHEMBL925760

实验名称：Inhibition of CARM1-mediated methylation of CA150 at 100 uM after 90 mins by scintill... 来源：ChEMBL 靶标：Histone-arginine methyltransferase CARM1 External Id：CHEMBL1804748

实验名称：Inhibition of histone H4R3 methylation in human U937 cells at 50 uM after 24 hrs 来源：ChEMBL 靶标：U-937 External Id：CHEMBL925761

实验名称：Inhibition of CARM1-mediated methylation of PABP1 at 100 uM after 90 mins by scintill... 来源：ChEMBL 靶标：Histone-arginine methyltransferase CARM1 External Id：CHEMBL1804747

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CARM1-IN-1英文别名

• CARM1-IN-1