L-655,240

• 常用名: L-655,240
• 英文名: L-655,240
• CAS号: 103253-15-2
• 分子量: 373.84800
• 密度: 1.22g/cm3
• 沸点: 548.7ºC at 760mmHg
• 分子式: C₂₁H₂₁ClFNO₂
• 熔点: N/A
• 闪点: 285.7ºC

L-655,240用途

L 655240是血栓素拮抗剂。L 655240减轻冠状动脉闭塞犬模型中早期缺血和再灌注诱发的心律失常。L 655240还涉及癌症和自身免疫性疾病[1]。

L-655,240名称

• 英文名: 3-[1-[(4-chlorophenyl)methyl]-5-fluoro-3-methylindol-2-yl]-2,2-dimethylpropanoic acid

L-655,240生物活性

• 描述: L 655240是血栓素拮抗剂。L 655240减轻冠状动脉闭塞犬模型中早期缺血和再灌注诱发的心律失常。L 655240还涉及癌症和自身免疫性疾病[1]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
• 体外研究: L 655240(7 nM)抑制人血小板中内过氧化物诱导的聚集[1]。
• 体内研究: L 655240(0.3毫克/千克静脉注射；单次剂量) 改变犬类模型的发热率、动脉和肺动脉血压以及心输出量[1]。
• 参考文献:

  [1]. Wainwright CL, et al. The effects of L655,240, a selective thromboxane and prostaglandin endoperoxide antagonist, on ischemia- and reperfusion-induced cardiac arrhythmias. J Cardiovasc Pharmacol. 1988 Sep;12(3):264-71.

L-655,240物理化学性质

• 密度: 1.22g/cm3
• 沸点: 548.7ºC at 760mmHg
• 分子式: C₂₁H₂₁ClFNO₂
• 分子量: 373.84800
• 闪点: 285.7ºC
• 精确质量: 373.12400
• PSA: 42.23000
• LogP: 5.44380
• InChIKey: JLPYLHLUHJOPNL-UHFFFAOYSA-N
• SMILES: Cc1c(CC(C)(C)C(=O)O)n(Cc2ccc(Cl)cc2)c2ccc(F)cc12
• 蒸汽压: 7.1E-13mmHg at 25°C
• 折射率: 1.581

L-655,240安全信息

• 危害码 (欧洲): Xi: Irritant;
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S36/37/39

L-655,240靶点实验

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L-655,240英文别名

• N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu
• L-655,240
• Lopac-L-9539
• Tocris-1698