克林沙星

更新时间：2024-01-02 10:41:47

克林沙星结构式	常用名	克林沙星	英文名	Clinafloxacin
	CAS号	105956-97-6	分子量	365.78700
	密度	1.573 g/cm3	沸点	592.3ºC at 760 mmHg
	分子式	C₁₇H₁₇ClFN₃O₃	熔点	253-258ºC
	MSDS	中文版美版	闪点	312ºC
	符号	GHS08	信号词	Warning

克林沙星用途

Clinafloxacin(PD-127391)是氟喹诺酮抗生素。

中文名	克林沙星
英文名	7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
中文别名	罗非考昔 \| 7-(3-氨基-1-吡咯烷基)-1-环丙基-6-氟-8-氯-1,4-二氢-4-氧代-3-喹啉羧酸 \| 1-环丙基-6-氟-7-(3-氨基吡咯烷-1-基)-8-氯-1,4-二氢-4-氧-喹啉-3-羧酸
英文别名	更多

描述	Clinafloxacin(PD-127391)是氟喹诺酮抗生素。
相关类别	信号通路 >> 抗感染 >> 细菌研究领域 >> 感染
参考文献	[1]. Humphrey, G.H., et al., Pharmacokinetics of clinafloxacin enantiomers in humans. J Clin Pharmacol, 1999. 39(11): p. 1143-50. [2]. Pan, X.S. and L.M. Fisher, DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae. Antimicrob Agents Chemother, 1998. 42(11): p. 2810-6. [3]. Jorgensen, J.H., et al., Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother, 2000. 44(11): p. 2962-8.

描述

Clinafloxacin(PD-127391)是氟喹诺酮抗生素。

相关类别

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

参考文献

[1]. Humphrey, G.H., et al., Pharmacokinetics of clinafloxacin enantiomers in humans. J Clin Pharmacol, 1999. 39(11): p. 1143-50.

[2]. Pan, X.S. and L.M. Fisher, DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae. Antimicrob Agents Chemother, 1998. 42(11): p. 2810-6.

[3]. Jorgensen, J.H., et al., Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother, 2000. 44(11): p. 2962-8.

密度	1.573 g/cm3
沸点	592.3ºC at 760 mmHg
熔点	253-258ºC
分子式	C₁₇H₁₇ClFN₃O₃
分子量	365.78700
闪点	312ºC
精确质量	365.09400
PSA	88.56000
LogP	3.12980
外观性状	白色至淡黄色结晶粉末
蒸汽压	7.14E-15mmHg at 25°C
折射率	1.684
储存条件	2-8°C

符号	GHS08
信号词	Warning
危害声明	H361d
警示性声明	P281
危害码 (欧洲)	Xi
风险声明 (欧洲)	R36/37/38
安全声明 (欧洲)	S26-S36
危险品运输编码	NONH for all modes of transport
RTECS号	VB1800600
海关编码	2933990090

8-氯-1-环丙基-6,7-二...

101987-89-7

克林沙星

105956-97-6

文献：Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991

8-chloro-1-cycl...

105956-96-5

克林沙星

105956-97-6

文献：Journal of Medicinal Chemistry, , vol. 31, p. 983 - 991

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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J. Vet. Pharmacol. Ther. 38(2) , 123-9, (2015)

The objectives of this study were to investigate the pharmacokinetics of danofloxacin and its metabolite N-desmethyldanofloxacin and to determine their concentrations in synovial fluid after administr...

Accumulation of garenoxacin by Bacteroides fragilis compared with that of five fluoroquinolones.

J. Antimicrob. Chemother. 52(4) , 605-9, (2003)

Garenoxacin is a novel des-F(6)-quinolone with good anti-anaerobe activity. The accumulation of garenoxacin and five other quinolones in the presence and absence of a variety of efflux pump inhibitors...

Synthesis and antibacterial activity of novel pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid derivatives carrying the 3-cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl group as a C-10 substituent.

J. Med. Chem. 51 , 3238-49, (2008)

Novel pyrido[1,2,3- de][1,4]benzoxazine-6-carboxylic acid derivatives 5- 9 carrying a 3-cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl moiety at the C-10 position were synthesized and their in vi...

MFCD00865120

Clinafloxacin

7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid