克林沙星

• 常用名: 克林沙星
• 英文名: Clinafloxacin
• CAS号: 105956-97-6
• 分子量: 365.78700
• 密度: 1.573 g/cm3
• 沸点: 592.3ºC at 760 mmHg
• 分子式: C₁₇H₁₇ClFN₃O₃
• 熔点: 253-258ºC
• 闪点: 312ºC
• 符号: GHS08
• 信号词: Warning

克林沙星用途

Clinafloxacin(PD-127391)是氟喹诺酮抗生素。

克林沙星名称

• 中文名: 克林沙星
• 英文名: 7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• 中文别名: 罗非考昔 | 7-(3-氨基-1-吡咯烷基)-1-环丙基-6-氟-8-氯-1,4-二氢-4-氧代-3-喹啉羧酸 | 1-环丙基-6-氟-7-(3-氨基吡咯烷-1-基)-8-氯-1,4-二氢-4-氧-喹啉-3-羧酸

克林沙星生物活性

• 描述: Clinafloxacin(PD-127391)是氟喹诺酮抗生素。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染
• 参考文献:

  [1]. Humphrey, G.H., et al., Pharmacokinetics of clinafloxacin enantiomers in humans. J Clin Pharmacol, 1999. 39(11): p. 1143-50.

  [2]. Pan, X.S. and L.M. Fisher, DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae. Antimicrob Agents Chemother, 1998. 42(11): p. 2810-6.

  [3]. Jorgensen, J.H., et al., Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother, 2000. 44(11): p. 2962-8.

克林沙星物理化学性质

• 密度: 1.573 g/cm3
• 沸点: 592.3ºC at 760 mmHg
• 熔点: 253-258ºC
• 分子式: C₁₇H₁₇ClFN₃O₃
• 分子量: 365.78700
• 闪点: 312ºC
• 精确质量: 365.09400
• PSA: 88.56000
• LogP: 3.12980
• InChIKey: QGPKADBNRMWEQR-UHFFFAOYSA-N
• SMILES: NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)cn(C4CC4)c3c2Cl)C1
• 外观性状: 白色至淡黄色结晶粉末
• 蒸汽压: 7.14E-15mmHg at 25°C
• 折射率: 1.684
• 储存条件: 2-8°C

克林沙星安全信息

• 符号: GHS08
• 信号词: Warning
• 危害声明: H361d
• 警示性声明: P281
• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26-S36
• 危险品运输编码: NONH for all modes of transport
• RTECS号: VB1800600
• 海关编码: 2933990090

克林沙星海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

克林沙星靶点实验

查看更多实验

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Minimum inhibitory concentration against Escherichia coli 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL679318

实验名称：Increase the activity of the Burkholderia fixLJ 2-component system 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Burkholderia multivorans External Id：HMS1625

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Minimum inhibitory concentration against Escherichia coli DNA-gyrase in supercoiling ... 来源：ChEMBL 靶标：DNA gyrase subunit B External Id：CHEMBL664852

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen 来源：NCGC 靶标：N/A External Id：SMAD3201

实验名称：uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay 来源：Burnham Center for Chemical Genomics 靶标：cystic fibrosis transmembrane conductance regulator [Homo sapiens] External Id：SBCCG-A764-CF-PAF-Primary-Assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ant... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_ANT_FLUO8_1536_1X%INH PRUN

实验名称：qHTS for Inhibitors of TGF-b 来源：NCGC 靶标：Smad3 [Homo sapiens] External Id：SMAD3101

实验名称：In vitro antibacterial activity was tested for Escherichia coli H560 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL682186

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克林沙星英文别名

• MFCD00865120
• Clinafloxacin
• 7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid