LDN 193719

• 常用名: LDN 193719
• 英文名: ML 347
• CAS号: 1062368-49-3
• 分子量: 352.389
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₂H₁₆N₄O
• 熔点: 209-210℃
• 闪点: N/A

LDN 193719用途

ML347(DN193719)是ALK1/ALK2选择性抑制剂,IC50分别为46/32 nM,比对ALK3的抑制性高300倍。

LDN 193719名称

• 中文名: 5-[6-(4-甲氧基苯基)吡唑并[1,5-a]嘧啶-3-基]喹啉
• 英文名: ml347

LDN 193719生物活性

• 描述: ML347(DN193719)是ALK1/ALK2选择性抑制剂,IC50分别为46/32 nM,比对ALK3的抑制性高300倍。
• 相关类别:
  信号通路 >> TGF-beta/Smad 信号通路 >> TGF-β受体
  研究领域 >> 癌症
• 参考文献:

  [1]. Engers DW, et al. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.

LDN 193719物理化学性质

• 密度: 1.3±0.1 g/cm3
• 熔点: 209-210℃
• 分子式: C₂₂H₁₆N₄O
• 分子量: 352.389
• 精确质量: 352.132416
• PSA: 52.31000
• LogP: 2.63
• InChIKey: FVRYPYDPKSZGNS-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=C5C=CC=NC5=CC=C4)N=C2
• 外观性状: 粉末
• 折射率: 1.695
• 储存条件: -20℃

LDN 193719安全信息

• 危险品运输编码: 3077

LDN 193719靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

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LDN 193719英文别名

• 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline