ML 347
Modify Date: 2024-01-11 12:12:29
ML 347 structure
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Common Name | ML 347 | ||
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| CAS Number | 1062368-49-3 | Molecular Weight | 352.389 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C22H16N4O | Melting Point | 209-210℃ | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of ML 347ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs. ALK3.IC50 value:Target: ALK1/ALK2ML347 has IC50’s of 46 and 32 nM, respectively, against ALK1 and ALK2; however, the IC50 against ALK3 is 10,800 nM, >300-fold selective over ALK3. ML347 is completely inactive against allthe other kinases tested (with weak activity against ALK6, 9830 nM and KDR (VEGFR2)19,700 nM). ML347 is potent in the BMP4 cell assay (152 nM). |
| Name | ml347 |
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| Synonym | More Synonyms |
| Description | ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs. ALK3.IC50 value:Target: ALK1/ALK2ML347 has IC50’s of 46 and 32 nM, respectively, against ALK1 and ALK2; however, the IC50 against ALK3 is 10,800 nM, >300-fold selective over ALK3. ML347 is completely inactive against allthe other kinases tested (with weak activity against ALK6, 9830 nM and KDR (VEGFR2)19,700 nM). ML347 is potent in the BMP4 cell assay (152 nM). |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
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| Melting Point | 209-210℃ |
| Molecular Formula | C22H16N4O |
| Molecular Weight | 352.389 |
| Exact Mass | 352.132416 |
| PSA | 52.31000 |
| LogP | 2.63 |
| Index of Refraction | 1.695 |
| Storage condition | -20℃ |
| RIDADR | 3077 |
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| Quinoline, 5-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- |
| 5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline |