ML-335

• 常用名: ML-335
• 英文名: ML-335
• CAS号: 1069498-96-9
• 分子量: 408.533
• 密度: 1.1±0.1 g/cm3
• 沸点: 562.5±50.0 °C at 760 mmHg
• 分子式: C₂₅H₃₂N₂O₃
• 熔点: N/A
• 闪点: 294.0±30.1 °C
• 符号: GHS07
• 信号词: Warning

ML-335用途

CYM51010是μ-阿片受体-δ-阿片受体异二聚体的偏置配体,EC50为403nm。CYM51010具有与吗啡相似的抗伤害性活性,但耐受性发展和戒断症状水平降低[1]。

ML-335名称

• 英文名: Ethyl 1-(4-acetamidobenzyl)-4-(2-phenylethyl)-4-piperidinecarboxy late

ML-335生物活性

• 描述: CYM51010是μ-阿片受体-δ-阿片受体异二聚体的偏置配体,EC50为403nm。CYM51010具有与吗啡相似的抗伤害性活性,但耐受性发展和戒断症状水平降低[1]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体
  信号通路 >> 神经信号通路 >> 阿片受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Pinello C, et al. Characterization of an agonist probe for opioid receptor mu 1 (OPRM1)-opioid receptor delta 1 (OPRD1) heterodimerization. 2012 Dec 17 [updated 2013 Apr 5]. In: Probe Reports from the NIH Molecular Libraries Program [Internet].

ML-335物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 562.5±50.0 °C at 760 mmHg
• 分子式: C₂₅H₃₂N₂O₃
• 分子量: 408.533
• 闪点: 294.0±30.1 °C
• 精确质量: 408.241302
• PSA: 62.13000
• LogP: 3.98
• InChIKey: VUXRYYSKTWDPLO-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1(CCc2ccccc2)CCN(Cc2ccc(NC(C)=O)cc2)CC1
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.578

ML-335MSDS

ML-335MSDS英文版

ML-335安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 危险品运输编码: NONH for all modes of transport

ML-335靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Specificity screen against TRPC6 for compounds that activate transient receptor poten... 来源：Johns Hopkins Ion Channel Center 靶标：short transient receptor potential channel 6 [Mus musculus] External Id：TRPC4_AG_Counter_C6

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Specificity screen against TRPC6 for compounds that inhibit transient receptor potent... 来源：Johns Hopkins Ion Channel Center 靶标：short transient receptor potential channel 6 [Mus musculus] External Id：TRPC4_Inh_Counter_C6

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

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ML-335英文别名

• 4-Piperidinecarboxylic acid, 1-[[4-(acetylamino)phenyl]methyl]-4-(2-phenylethyl)-, ethyl ester
• Ethyl 1-(4-acetamidobenzyl)-4-(2-phenylethyl)-4-piperidinecarboxylate