GRL0617

• 常用名: GRL0617
• 英文名: GRL 0617
• CAS号: 1093070-16-6
• 分子量: 304.38600
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₀N₂O
• 熔点: N/A
• 闪点: N/A

GRL0617用途

GRL0617 是一种强效、选择性和竞争性的 SARS-CoV PLpro/deubiquitinase 的非共价抑制剂,其 IC50 值为 0.6 μM,Ki 值为 0.49 μM.

GRL0617名称

• 中文名: 5-氨基-2-甲基-n-(1r-萘-1-基-乙基)苯甲酰胺
• 英文名: 5-amino-2-methyl-N-(2-naphthalen-1-ylethyl)benzamide

GRL0617生物活性

• 描述: GRL0617 是一种强效、选择性和竞争性的 SARS-CoV PLpro/deubiquitinase 的非共价抑制剂,其 IC50 值为 0.6 μM,Ki 值为 0.49 μM.
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 细胞周期/DNA损伤 >> 去泛素化酶
  信号通路 >> 抗感染 >> SARS冠状病毒
• 靶点实验:

  IC50: 0.6 μM (SARS-CoV PLpro)[1]

• 参考文献:

  [1]. Ratia K, et al. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24.

GRL0617物理化学性质

• 分子式: C₂₀H₂₀N₂O
• 分子量: 304.38600
• 精确质量: 304.15800
• PSA: 58.61000
• LogP: 4.85890
• InChIKey: UVERBUNNCOKGNZ-CQSZACIVSA-N
• SMILES: Cc1ccc(N)cc1C(=O)NC(C)c1cccc2ccccc12
• 储存条件: -20°C，密闭，干燥

GRL0617靶点实验

查看更多实验

实验名称：Inhibition of SARS-CoV-2 PLpro assessed as viral PLpro-mediated deISGylation using IS... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5043146

实验名称：Inhibition of SARS-CoV-2 PLpro assessed as viral PLpro-mediated deubiquitination usin... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5043145

实验名称：SPR Binding Assay from US Patent US20240166598: "COMPOUNDS, COMPOSITIONS, AND METHODS... 来源：BindingDB 靶标：N/A External Id：BindingDB_12069_2

实验名称：Binding affinity to CMS sensor chip immobilized His-tagged SARS-CoV-2 PLpro assessed ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5043144

实验名称：Inhibition of SARS-CoV-2 PLpro using Z-RLRGG-AMC as substrate preincubated for 10 min... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5043143

实验名称：Secondary Binding Analysis by Surface Plasmon Resonance from Article 10.1021/acs.jmed... 来源：BindingDB 靶标：N/A External Id：BindingDB_9878_2

实验名称：Inhibition of recombinant SARS CoV-2 PL protease assessed as deubiquitination activit... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL5326739

实验名称：No assay is provided from Article 10.1002/med.21724: "The recent outbreaks of human c... 来源：BindingDB 靶标：N/A External Id：BindingDB_8918_1

实验名称：Inhibition of full-length SARS-CoV-2 PLpro expressed in Escherichia coli BL21(DE3) us... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL5109239

实验名称：Inhibition of full-length SARS-CoV-2 PLpro expressed in Escherichia coli BL21(DE3) us... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL5109240

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GRL0617英文别名

• I06-1403
• 5-azanyl-2-methyl-N-(2-naphthalen-1-ylethyl)benzamide
• 5-amino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide
• 5-amino-2-methyl-N-[2-(1-naphthalenyl)ethyl]benzamide