HadAB-IN-1

• 常用名: HadAB-IN-1
• 英文名: HadAB-IN-1
• CAS号: 1097120-47-2
• 分子量: 482.78
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₇BrClN₃O₃S
• 熔点: N/A
• 闪点: N/A

HadAB-IN-1用途

HadAB-IN-1是一种有效的HadAB抑制剂。HadAB-IN-1抑制HadAB酶复合物活性,IC50值为0.03μM。HadAB-IN-1也影响结核分枝杆菌(Mtb)中分枝杆菌酸的生物合成。HadAB-IN-1可用于结核病(TB)的研究[1]。

HadAB-IN-1名称

• 英文名: HadAB-IN-1

HadAB-IN-1生物活性

• 描述: HadAB-IN-1是一种有效的HadAB抑制剂。HadAB-IN-1抑制HadAB酶复合物活性,IC50值为0.03μM。HadAB-IN-1也影响结核分枝杆菌(Mtb)中分枝杆菌酸的生物合成。HadAB-IN-1可用于结核病(TB)的研究[1]。
• 相关类别:
  研究领域 >> 感染
  研究领域 >> 炎症/免疫
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  IC50: 0.03 μM (HadAB enzyme complexes); MIC50: 4.7 μM (Mtb)[1].

• 体外研究: HadAB-IN-1对HadAB酶复合物具有抑制活性,IC50值为0.03μM[1]。HadAB-IN-1可以抑制结核分枝杆菌(Mtb),MIC50值为4.7μM[1]。

HadAB-IN-1物理化学性质

• 分子式: C₁₉H₁₇BrClN₃O₃S
• 分子量: 482.78
• InChIKey: HJRIVXBUFBERIX-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)NC(=O)CCc1cn(-c2ccc(Br)cc2)nc1-c1ccc(Cl)cc1

HadAB-IN-1靶点实验

查看更多实验

实验名称：Total body clearance in iv dosed C57BL/6 mouse measured up to 24 hrs by LC-MS/MS anal... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4844147

实验名称：Volume of distribution in iv dosed C57BL/6 mouse measured up to 24 hrs by LC-MS/MS an... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4844146

实验名称：Antimycobacterial activity against Mycobacterium tuberculosis H37Rv in presence of mi... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL4844114

实验名称：Terminal half life in iv dosed C57BL/6 mouse measured up to 24 hrs by LC-MS/MS analys... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4844145

实验名称：Plasma protein binding in human assessed as unbound fraction at 5 uM by LC-MS/MS anal... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4844144

实验名称：AUC (0 to t) in iv dosed C57BL/6 mouse measured up to 24 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4844149

实验名称：Unbound clearance in iv dosed C57BL/6 mouse measured up to 24 hrs by LC-MS/MS analysi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4844148

实验名称：Metabolic stability in mouse liver microsomes assessed as compound remaining at 1 uM ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4844143

实验名称：Metabolic stability in rat liver microsomes assessed as compound remaining at 1 uM by... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4844142

实验名称：Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4844141

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