Luffariellolide

• 常用名: Luffariellolide
• 英文名: Luffariellolide
• CAS号: 111149-87-2
• 分子量: 386.567
• 密度: 1.0±0.1 g/cm3
• 沸点: 541.7±50.0 °C at 760 mmHg
• 分子式: C₂₅H₃₈O₃
• 熔点: N/A
• 闪点: 209.3±22.9 °C

Luffariellolide用途

丝瓜列醇是人滑液磷脂酶A2(HSF-PLA2)的抑制剂(IC50=5μM)。丝瓜列醇有效抑制佛波酯(PMA)诱导的耳水肿(ED50=50μg/耳)[1]。

Luffariellolide名称

• 英文名: 3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one

Luffariellolide生物活性

• 描述: 丝瓜列醇是人滑液磷脂酶A2(HSF-PLA2)的抑制剂(IC50=5μM)。丝瓜列醇有效抑制佛波酯(PMA)诱导的耳水肿(ED50=50μg/耳)[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷脂
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. K B Glaser, et al. Cellular and topical in vivo inflammatory murine models in the evaluation of inhibitors of phospholipase A2. Skin Pharmacol. 1995;8(6):300-8.

Luffariellolide物理化学性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 541.7±50.0 °C at 760 mmHg
• 分子式: C₂₅H₃₈O₃
• 分子量: 386.567
• 闪点: 209.3±22.9 °C
• 精确质量: 386.282104
• PSA: 46.53000
• LogP: 7.27
• InChIKey: JPWPYTMXSXYUPG-QZPYEDBESA-N
• SMILES: CC(=CCCC1=CC(=O)OC1O)CCC=C(C)CCC1=C(C)CCCC1(C)C
• 蒸汽压: 0.0±3.3 mmHg at 25°C
• 折射率: 1.517

Luffariellolide靶点实验

查看更多实验

实验名称：Inhibition of bee venom PLA2 来源：ChEMBL 靶标：Phospholipase A2 External Id：CHEMBL948647

实验名称：Inhibition of human synovial fluid-PLA2 来源：ChEMBL 靶标：Phospholipase A2, membrane associated External Id：CHEMBL948648

实验名称：Antimicrobial activity against Cladosporium herbarum DSM 63422 at 5 ug/disk after 24 ... 来源：ChEMBL 靶标：Cladosporium herbarum External Id：CHEMBL998443

实验名称：Antimicrobial activity against Candida albicans at 5 ug/disk after 24 hrs 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL998442

实验名称：Antimicrobial activity against Bacillus subtilis DSM 2109 at 10 ug/disk after 24 hrs 来源：ChEMBL 靶标：Bacillus subtilis External Id：CHEMBL998445

实验名称：Antimicrobial activity against Staphylococcus aureus ATCC 210923 at 10 ug/disk after ... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL998444

实验名称：Antimicrobial activity against Staphylococcus aureus ATCC 25923 at 5 ug/disk after 24... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL998439

实验名称：Antimicrobial activity against Escherichia coli DSM 10290 at 5 ug/disk after 24 hrs 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL998441

实验名称：Antimicrobial activity against Bacillus subtilis DSM 2109 at 5 ug/disk after 24 hrs 来源：ChEMBL 靶标：Bacillus subtilis External Id：CHEMBL998440

实验名称：Cytotoxicity against rat PC12 cells by MTT assay 来源：ChEMBL 靶标：PC-12 External Id：CHEMBL998451

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Luffariellolide英文别名

• 4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,7-dien-1-yl]-5-hydroxyfuran-2(5H)-one
• Luffariellolide
• 4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadien-1-yl]-5-hydroxy-2(5H)-furanone