Sildenafil-d3

• 常用名: Sildenafil-d3
• 英文名: Sildenafil-d3
• CAS号: 1126745-90-1
• 分子量: 477.595
• 密度: 1.4±0.1 g/cm3
• 沸点: 672.4±65.0 °C at 760 mmHg
• 分子式: C₂₂H₂₇D₃N₆O₄S
• 熔点: N/A
• 闪点: 360.5±34.3 °C

Sildenafil-d3用途

西地那非d3是氘标记的西地那非d3。西地那非(UK-92480)是一种有效的磷酸二酯酶5型(PDE5)抑制剂,IC50为5.22 nM。

Sildenafil-d3名称

• 中文名: 西地那非-d3
• 英文名: Sildenafil-d3

Sildenafil-d3生物活性

• 描述: 西地那非d3是氘标记的西地那非d3。西地那非(UK-92480)是一种有效的磷酸二酯酶5型(PDE5)抑制剂,IC50为5.22 nM。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 心血管疾病
  信号通路 >> 代谢酶/蛋白酶 >> 磷酸二酯酶(PDE)
• 参考文献:

  [1]. Wang Z, et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov;10(11):2790-7

  [2]. [2].Li BB, et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl). 2011 Sep;124(17):2733-40.

  [3]. [3]. Moretti R, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28;13(1):95.

  [4]. Korkmaz MF, et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar;33(2):204-11.

Sildenafil-d3物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 672.4±65.0 °C at 760 mmHg
• 分子式: C₂₂H₂₇D₃N₆O₄S
• 分子量: 477.595
• 闪点: 360.5±34.3 °C
• 精确质量: 477.223755
• PSA: 121.80000
• LogP: 2.27
• 外观性状: 固体
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.665
• 储存条件: 2-8°C，密封，干燥

Sildenafil-d3英文别名

• 7H-pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[[4-(methyl-d)-1-piperazinyl]sulfonyl]phenyl]-1,6-dihydro-1-methyl-3-propyl-
• 5-[2-ethoxy-5-[4-(trideuteriomethyl)piperazin-1-yl]sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidin-7-one
• 7H-Pyrazolo[4,3-d]pyrimidin-7-one, 5-[2-ethoxy-5-[[4-(methyl-d)-1-piperazinyl]sulfonyl]phenyl]-1,4-dihydro-1-methyl-3-propyl-
• 5-(2-Ethoxy-5-{[4-(H)methylpiperazin-1-yl]sulfonyl}phenyl)-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
• 5-(2-Ethoxy-5-{[4-(H)methyl-1-piperazinyl]sulfonyl}phenyl)-1-methyl-3-propyl-1,4-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one