Robotnikinin

• 常用名: Robotnikinin
• 英文名: Robotnikinin
• CAS号: 1132653-79-2
• 分子量: 454.95
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₂₇ClN₂O₄
• 熔点: N/A
• 闪点: N/A

Robotnikinin用途

Robotnikinin是一种小分子,能够结合并抑制Smo上游声波刺猬(Shh)信号的活性[1][2]。

Robotnikinin名称

• 中文名: 尼古丁宁
• 英文名: Robotnikinin

Robotnikinin生物活性

• 描述: Robotnikinin是一种小分子,能够结合并抑制Smo上游声波刺猬(Shh)信号的活性[1][2]。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> Hedgehog
  研究领域 >> 炎症/免疫
• 体外研究: Robotnikinin在浓度介于1.56μM和25μM之间时表现出ShhN结合能力,根据动力学数据得出KD为3.1μM[2]。Robotnikinin(50µM)可防止ShhN诱导的LC3-II增加[3]。Robotnikinin(5μM)下调与HS-5细胞共培养的H929和U266细胞系中的经典NF-κB途径蛋白,表明MM中Hh信号与NF-κB途径之间存在联系[4]。RT-PCR[4]细胞系：NCI-H929或U266细胞。浓度：5μM,孵育时间：48h。结果：在与HS-5细胞共培养的H929和U266细胞系中,经典NF-κB途径蛋白表达下调。
• 参考文献:

  [1]. Manuel Hitzenberger, et al. The Binding Mode of the Sonic Hedgehog Inhibitor Robotnikinin, a Combined Docking and QM/MM MD Study. Front Chem

  [2]. Benjamin Z Stanton, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5(3):154-6.

  [3]. Ronald S Petralia, et al. Sonic hedgehog promotes autophagy in hippocampal neurons. Biol Open. 2013 Apr 8;2(5):499-504.

  [4]. Ke Cai, et al. Targeting the cross-talk between the hedgehog and NF-κB signaling pathways in multiple myeloma. Leuk Lymphoma. 2019 Mar;60(3):772-781.

Robotnikinin物理化学性质

• 分子式: C₂₅H₂₇ClN₂O₄
• 分子量: 454.95
• 精确质量: 454.16600
• PSA: 84.50000
• LogP: 4.82300
• InChIKey: DRDSZZCLAHXSAE-UHFFFAOYSA-N
• SMILES: O=C(CC1CC=CCCC(=O)OC(c2ccccc2)CNC1=O)NCc1ccc(Cl)cc1

Robotnikinin靶点实验

查看更多实验

实验名称：Inhibition of of N-terminal N-palmitoylated Shh-mediated Gli1 transcription in human ... 来源：ChEMBL 靶标：Sonic hedgehog protein External Id：CHEMBL1220920

实验名称：Effect on SAG-induced Gli1 transcription in mouse C3H10T1/2 cells at 103 to 25000 nM ... 来源：ChEMBL 靶标：C3H 10T1/2 External Id：CHEMBL2153867

实验名称：Inhibition of of N-terminal N-palmitoylated Shh-mediated Gli1 transcription in human ... 来源：ChEMBL 靶标：Sonic hedgehog protein External Id：CHEMBL1220919

实验名称：Inhibition of of N-terminal N-palmitoylated Shh-mediated Gli1 transcription in human ... 来源：ChEMBL 靶标：Sonic hedgehog protein External Id：CHEMBL1220918

实验名称：Inhibition of of N-terminal N-palmitoylated Shh-mediated Gli2 transcription in human ... 来源：ChEMBL 靶标：Sonic hedgehog protein External Id：CHEMBL1220917

实验名称：Displacement of BODIPY-cyclopamine from Smo expressed in HEK293T cells after 30 mins 来源：ChEMBL 靶标：Smoothened homolog External Id：CHEMBL1220916

实验名称：Inhibition of N-terminal Shh-induced differentiation in mouse C3H10T1/2 cells assesse... 来源：ChEMBL 靶标：Sonic hedgehog protein External Id：CHEMBL1220915

实验名称：Inhibition of N-terminal Shh-induced differentiation in mouse C3H10T1/2 cells assesse... 来源：ChEMBL 靶标：Sonic hedgehog protein External Id：CHEMBL1220914

实验名称：Inhibition of N-palmitoylated Shh in mouse Shh Light2 cells at 6.3 to 50 uM after 30 ... 来源：ChEMBL 靶标：Sonic hedgehog protein External Id：CHEMBL1220913

实验名称：Binding affinity to recombinant Shh N-terminal peptide by surface plasma resonance 来源：ChEMBL 靶标：Sonic hedgehog protein External Id：CHEMBL1101550

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Robotnikinin英文别名

• R-lactic acid tert-butyl ester
• bovine dodecapeptide
• D-lactic acid tert-butyl ester
• RLCRIVVIRVCR 3-11 disulfide