Illudin M

• 常用名: Illudin M
• 英文名: Illudin M
• CAS号: 1146-04-9
• 分子量: 248.31700
• 密度: 1.24g/cm3
• 沸点: 452.4ºC at 760mmHg
• 分子式: C₁₅H₂₀O₃
• 熔点: N/A
• 闪点: 241.5ºC

Illudin M用途

Illudin M 是一种细胞毒性真菌倍半萜,可以从 Omphalotus olearius 蘑菇培养基中分离得到的。Illudin M 能使 DNA 烷基化。Illudin M 具有抗肿瘤活性。

Illudin M名称

• 英文名: Spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one, 2',3'-dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethyl-,(3'S-trans)

Illudin M生物活性

• 描述: Illudin M 是一种细胞毒性真菌倍半萜,可以从 Omphalotus olearius 蘑菇培养基中分离得到的。Illudin M 能使 DNA 烷基化。Illudin M 具有抗肿瘤活性。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> DNA烷基化剂/交联剂
• 体外研究: Illudin M(0.01-10μM；24-120小时)在体外具有细胞毒性和诱导凋亡作用[1]。细胞凋亡分析[1]细胞系：Panc-1胰腺癌、HT-29结肠癌、非恶性包皮成纤维细胞(HFs)浓度：0.01μM、1μM、10μM孵育时间：24小时、48小时、72小时、96小时、120小时结果：肿瘤细胞凋亡诱导率相当(Panc-1 86%,HT-29 48%),但HF中的一个更大(89%)。
• 参考文献:

  [1]. Rainer Schobert, et al. Conjugates of the fungal cytotoxin illudin M with improved tumour specificity. Bioorg Med Chem. 2008 Sep 15;16(18):8592-7.

  [2]. Dr. Philipp Le, et al. A Chemical Proteomic Analysis of Illudin‐Interacting Proteins. Chemistry. 2019 Sep 25; 25(54): 12644–12651.

Illudin M物理化学性质

• 密度: 1.24g/cm3
• 沸点: 452.4ºC at 760mmHg
• 分子式: C₁₅H₂₀O₃
• 分子量: 248.31700
• 闪点: 241.5ºC
• 精确质量: 248.14100
• PSA: 57.53000
• LogP: 1.74390
• InChIKey: QVMDIQLUNODCTG-OCCSQVGLSA-N
• SMILES: CC1=C2C(=CC(C)(C)C2O)C(=O)C(C)(O)C12CC2
• 蒸汽压: 4.36E-10mmHg at 25°C
• 折射率: 1.593
• 分子结构:

  1、 摩尔折射率：67.69

  2、 摩尔体积（cm³/mol）：199.7

  3、 等张比容（90.2K）：532.3

  4、 表面张力（dyne/cm）：50.4

  5、 极化率（10-24cm3）：26.83

Illudin M毒性和生态

Illudin M靶点实验

查看更多实验

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Cytotoxicity against human HT-29 cells assessed as viable cells at 1 uM after 120 hrs... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL994961

实验名称：Cytotoxicity against human PANC1 cells assessed as viable cells at 1 uM after 120 hrs... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL994960

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Cytotoxicity against HFF cells assessed as viable cells at 1 uM after 120 hrs by tryp... 来源：ChEMBL 靶标：HFF External Id：CHEMBL994963

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Cytotoxicity against HFF cells assessed as viable cells at 1 uM after 48 hrs by trypa... 来源：ChEMBL 靶标：HFF External Id：CHEMBL994962

实验名称：Chemical reactivity of the compound in aqueous HCl assessed as reaction rate 来源：ChEMBL 靶标：N/A External Id：CHEMBL3744204

实验名称：Cytotoxicity against human HT-29 cells assessed as viable cells at 1 uM after 48 hrs ... 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL994959

实验名称：Cytotoxicity against human PANC1 cells assessed as viable cells at 1 uM after 48 hrs ... 来源：ChEMBL 靶标：PANC-1 External Id：CHEMBL994958

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Illudin M英文别名

• illudin M
• (3'S,6'R)-2',3'-Dihydro-3',6'-dihydroxy-2',2',4',6'-tetramethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one
• (3'S,6'R)-2',3'-Dihydro-2',2',4',6'-tetramethylspiro(cyclopropane-1,5'-[5H]inden)-7'(6'H)-one