氯沙坦甲醛

• 常用名: 氯沙坦甲醛
• 英文名: Losartan Carboxaldehyde
• CAS号: 114798-36-6
• 分子量: 420.895
• 密度: 1.3±0.1 g/cm3
• 沸点: 666.7±65.0 °C at 760 mmHg
• 分子式: C₂₂H₂₁ClN₆O
• 熔点: 84-86 °C
• 闪点: 357.0±34.3 °C

氯沙坦甲醛用途

EXP3179是氯沙坦的重要中间醛代谢物。EXP3179没有AT1-R阻断活性,但能有效抑制内皮环氧化酶(COX)-2的表达。EXP3179具有强大的抗炎作用[1]。

氯沙坦甲醛名称

• 中文名: 氯沙坦甲醛
• 英文名: 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carbaldehyde
• 中文别名: 氯沙坦钾杂质 K

氯沙坦甲醛生物活性

• 描述: EXP3179是氯沙坦的重要中间醛代谢物。EXP3179没有AT1-R阻断活性,但能有效抑制内皮环氧化酶(COX)-2的表达。EXP3179具有强大的抗炎作用[1]。
• 相关类别:
  研究领域 >> 心血管疾病
  研究领域 >> 炎症/免疫
  信号通路 >> 免疫及炎症 >> COX
• 参考文献:

  [1]. Rossi GP. Losartan metabolite EXP3179: an AT1-receptor-independent treatment strategy for patients with the metabolic syndrome?. Hypertension. 2009;54(4):710-712.

氯沙坦甲醛物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 666.7±65.0 °C at 760 mmHg
• 熔点: 84-86 °C
• 分子式: C₂₂H₂₁ClN₆O
• 分子量: 420.895
• 闪点: 357.0±34.3 °C
• 精确质量: 420.146545
• PSA: 89.35000
• LogP: 5.09
• InChIKey: FQZSMTSTFMNWQF-UHFFFAOYSA-N
• SMILES: CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
• 蒸汽压: 0.0±2.0 mmHg at 25°C
• 折射率: 1.681
• 储存条件: 室温

氯沙坦甲醛靶点实验

查看更多实验

实验名称：Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibit... 来源：ChEMBL 靶标：Platelet glycoprotein VI External Id：CHEMBL3879206

实验名称：Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibit... 来源：ChEMBL 靶标：Platelet glycoprotein VI External Id：CHEMBL3879207

实验名称：Acid dissociation value was evaluated 来源：ChEMBL 靶标：N/A External Id：CHEMBL637336

实验名称：Blood pressure lowering activity in renal hypertensive rats after intravenous adminis... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL777833

实验名称：Inhibition against Angiotensin II receptor, type 1 来源：ChEMBL 靶标：Type-1 angiotensin II receptor External Id：CHEMBL650305

实验名称：Blood pressure lowering activity in renal hypertensive rats after peroral administrat... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL775091

实验名称：Inhibition of radioligand [3H]angiotensin II binding to angiotensin II receptor of ra... 来源：ChEMBL 靶标：Type-2 angiotensin II receptor External Id：CHEMBL651552

实验名称：Antagonist activity at GP6 receptor in human platelet rich plasma assessed as inhibit... 来源：ChEMBL 靶标：Platelet glycoprotein VI External Id：CHEMBL3879200

实验名称：Metabolic activation assessed as CYP2C9 activation-induced cytotoxicity in human HepG... 来源：ChEMBL 靶标：Cytochrome P450 2C9 External Id：CHEMBL3540746

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氯沙坦甲醛英文别名

• 2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-imidazole-5-carbaldehyde
• 2-butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carbaldehyde
• 2-Butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carbaldehyde
• 2-n-Butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-imidazole-5-carboxaldehyde
• 2-butyl-4-chloro-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>imidazole-5-carboxaldehyde
• [3H]-EXP 3179
• EXP 3179
• 2-butyl-4-chloro-5-formyl-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methylimidazole
• Losartan Carboxaldehyde
• 2-Butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carbaldehyde
• 2-Butyl-4-chloro-1-[[2 inverted exclamation mark-(1H-tetrazol-5-yl)[1,1 inverted exclamation mark-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde
• DUP 167