CI 972 (anhydrous)

• 常用名: CI 972 (anhydrous)
• 英文名: CI 972 (anhydrous)
• CAS号: 115787-68-3
• 分子量: 297.76400
• 密度: N/A
• 沸点: 602.2ºC at 760mmHg
• 分子式: C₁₁H₁₂ClN₅OS
• 熔点: N/A
• 闪点: 318ºC

CI 972 (anhydrous)用途

CI 972 anhydrous 是一会有效的,具有口服活性的,竞争性的嘌呤核苷磷酸化酶 (PNP) (Ki=0.83 μM),正在开发作为T细胞选择性免疫抑制剂。

CI 972 (anhydrous)名称

• 英文名: 2,6-diamino-7-(thiophen-3-ylmethyl)-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one,hydrochloride

CI 972 (anhydrous)生物活性

• 描述: CI 972 anhydrous 是一会有效的,具有口服活性的,竞争性的嘌呤核苷磷酸化酶 (PNP) (Ki=0.83 μM),正在开发作为T细胞选择性免疫抑制剂。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 炎症/免疫
• 靶点实验:

  Ki: 0.83 μM (PNP)[1]

• 体内研究: CI 972无水(5-150mg/kg; p.o.)在给予大鼠1小时后产生血浆肌苷的剂量依赖性升高[1]。
• 参考文献:

  [1]. Gilbertsen RB, et al. Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor. Adv Exp Med Biol. 1991;309A:41-4.

  [2]. Gilbertsen RB,et al. Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972. Biochem Biophys Res Commun. 1991 Aug 15;178(3):1351-8.

CI 972 (anhydrous)物理化学性质

• 沸点: 602.2ºC at 760mmHg
• 分子式: C₁₁H₁₂ClN₅OS
• 分子量: 297.76400
• 闪点: 318ºC
• 精确质量: 297.04500
• PSA: 142.55000
• LogP: 2.38120
• InChIKey: SLNICZJKQXPOJA-UHFFFAOYSA-N
• SMILES: Cl.Nc1nc2c(Cc3ccsc3)c(N)[nH]c2c(=O)[nH]1
• 蒸汽压: 1.87E-14mmHg at 25°C
• 储存条件: 2-8°C，干燥，密封

CI 972 (anhydrous)安全信息

• 危害码 (欧洲): Xi

CI 972 (anhydrous)靶点实验

查看更多实验

实验名称：Solubility in water 来源：ChEMBL 靶标：N/A External Id：CHEMBL632603

实验名称：Partition coefficient in octanol/water system was determined at pH 7.4, as a measure ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL633736

实验名称：Compound was tested for the inhibitory activity against purine nucleoside phosphoryla... 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL766697

实验名称：Compound was evaluated for the inhibitory activity against purine nucleoside phosphor... 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL766717

实验名称：Compound was evaluated for the inhibitory activity against purine nucleoside phosphor... 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL874026

实验名称：Apparent bioavailability in dogs at 15 mg/kg in an iv vs po dosing regimen 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL625955

实验名称：Compound was evaluated for the inhibitory activity against purine nucleoside phosphor... 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL766715

实验名称：Compound was evaluated for the inhibitory activity against purine nucleoside phosphor... 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL841675

实验名称：Compound was evaluated for the inhibitory activity against purine nucleoside phosphor... 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL766716

实验名称：Ability to inhibit purine nucleoside phosphorylase (PNP) 来源：ChEMBL 靶标：Purine nucleoside phosphorylase External Id：CHEMBL766705

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CI 972 (anhydrous)英文别名

• ci 972