CI 972 (anhydrous)
Modify Date: 2025-08-20 17:37:54
CI 972 (anhydrous) structure
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Common Name | CI 972 (anhydrous) | ||
|---|---|---|---|---|
| CAS Number | 115787-68-3 | Molecular Weight | 297.76400 | |
| Density | N/A | Boiling Point | 602.2ºC at 760mmHg | |
| Molecular Formula | C11H12ClN5OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 318ºC | |
Use of CI 972 (anhydrous)CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent[1][2]. |
| Name | 2,6-diamino-7-(thiophen-3-ylmethyl)-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent[1][2]. |
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| Related Catalog | |
| Target |
Ki: 0.83 μM (PNP)[1] |
| In Vivo | CI 972 anhydrous (5-150 mg/kg; p.o.) produces dose-dependent elevation of plasma inosine one hour after administration to rats[1]. |
| References |
| Boiling Point | 602.2ºC at 760mmHg |
|---|---|
| Molecular Formula | C11H12ClN5OS |
| Molecular Weight | 297.76400 |
| Flash Point | 318ºC |
| Exact Mass | 297.04500 |
| PSA | 142.55000 |
| LogP | 2.38120 |
| Vapour Pressure | 1.87E-14mmHg at 25°C |
| Hazard Codes | Xi |
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| ci 972 |