TC-I 2000

• 常用名: TC-I 2000
• 英文名: TC-I 2000
• CAS号: 1159996-20-9
• 分子量: 414.39500
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₁₈F₄N₂O
• 熔点: N/A
• 闪点: N/A

TC-I 2000用途

TRPM8-IN-1(实施例14)是一种瞬时受体电位melastatin-8(TRPM8)通道的抑制剂,IC50<5μM[1]。

TC-I 2000名称

• 英文名: N-(4-fluorophenyl)-1-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide

TC-I 2000生物活性

• 描述: TRPM8-IN-1(实施例14)是一种瞬时受体电位melastatin-8(TRPM8)通道的抑制剂,IC50<5μM[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 神经疾病
• 靶点实验:

  TRPM8:<5 μM (IC50)

• 参考文献:

  [1]. Norman, et al. Preparation of substituted dihydroisoquinoline derivatives for use as TRP-M8 receptor ligands. World Intellectual Property Organization, WO2009073203 A1. 2009-06-11.

TC-I 2000物理化学性质

• 分子式: C₂₃H₁₈F₄N₂O
• 分子量: 414.39500
• 精确质量: 414.13600
• PSA: 32.34000
• LogP: 6.03500
• InChIKey: ADCDUDFEGFKKQH-UHFFFAOYSA-N
• SMILES: O=C(Nc1ccc(F)cc1)N1CCc2ccccc2C1c1ccc(C(F)(F)F)cc1

TC-I 2000靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

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TC-I 2000英文别名

• sb 611812