IOWH-032

• 常用名: IOWH-032
• 英文名: IOWH032
• CAS号: 1191252-49-9
• 分子量: 545.180
• 密度: 1.7±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₂H₁₅Br₂N₃O₄
• 熔点: N/A
• 闪点: N/A

IOWH-032用途

IOWH-032是CFTR抑制剂,在T84和CHO-CFTR细胞实验中IC50为1.01 uM。

IOWH-032名称

• 中文名: 3-(3,5-二溴-4-羟基苯基)-N-[(4-苯氧基苯基)甲基]-1,2,4-恶二唑-5-甲酰胺
• 英文名: 3-(3,5-dibromo-4-oxocyclohexa-2,5-dien-1-ylidene)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide

IOWH-032生物活性

• 描述: IOWH-032是CFTR抑制剂,在T84和CHO-CFTR细胞实验中IC50为1.01 uM。
• 相关类别:
  信号通路 >> 跨膜转运 >> CFTR
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Doyle K, et al. Inhibitors Of The CFTR Chloride Ion Channel As Potential Treatment For Acute Secretory Diarrhea: Development Of 5-membered Heterocycles Suitable For Pre-clinical Evaluation

  [2]. de Hostos EL, et al. Developing novel antisecretory drugs to treat infectious diarrhea. Future Med Chem. 2011 Aug;3(10):1317-25.

IOWH-032物理化学性质

• 密度: 1.7±0.1 g/cm3
• 分子式: C₂₂H₁₅Br₂N₃O₄
• 分子量: 545.180
• 精确质量: 542.942932
• PSA: 97.22000
• LogP: 7.13
• 折射率: 1.665
• 储存条件: -20°C

IOWH-032安全信息

• 危害码 (欧洲): Xi

IOWH-032靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

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IOWH-032英文别名

• unii-8y3gdt6ywv
• s7329
• 3-(3,5-Dibromo-4-hydroxyphenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide
• IOWH032
• IOWH-032
• iowh 032