N-叔丁基苯硝酮-D14

• 常用名: N-叔丁基苯硝酮-D14
• 英文名: N-tert-Butyl-α-phenylnitrone-d14
• CAS号: 119391-92-3
• 分子量: 191.329
• 密度: 1.0±0.1 g/cm3
• 沸点: 283.3±23.0 °C at 760 mmHg
• 分子式: C₁₁HD₁₄NO
• 熔点: N/A
• 闪点: 118.5±15.4 °C

N-叔丁基苯硝酮-D14用途

N-叔丁基-α-苯基硝基酮d14是氘标记的N-叔丁基/α-苯基硝酮[1]。N-叔丁基-α-苯基硝酮是一种基于硝酮的自由基清除剂,可形成氮氧化物自旋加合物。N-叔丁基-α-苯基硝酮抑制COX2的催化活性。N-叔丁基-α-苯基硝酮具有强大的ROS清除、抗炎、神经保护、抗衰老和抗糖尿病活性,并可穿透血脑屏障[2][3][4][5]。

N-叔丁基苯硝酮-D14名称

• 中文名: N-叔丁基苯硝酮-D14
• 英文名: n-tert-butyl-d9-phenyl-d5-nitrone

N-叔丁基苯硝酮-D14生物活性

• 描述: N-叔丁基-α-苯基硝基酮d14是氘标记的N-叔丁基/α-苯基硝酮[1]。N-叔丁基-α-苯基硝酮是一种基于硝酮的自由基清除剂,可形成氮氧化物自旋加合物。N-叔丁基-α-苯基硝酮抑制COX2的催化活性。N-叔丁基-α-苯基硝酮具有强大的ROS清除、抗炎、神经保护、抗衰老和抗糖尿病活性,并可穿透血脑屏障[2][3][4][5]。
• 相关类别:
  信号通路 >> 免疫及炎症 >> COX
• 体外研究: 氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

  [2]. Zhenggang Zhou, et al. PBN Protects NP Cells From AAPH-induced Degenerative Changes by Inhibiting the ERK1/2 Pathway. Connect Tissue Res. 2020 Mar 30;1-10.

  [3]. Lei Zhao, et al. Reactive Oxygen Species Contribute to Lipopolysaccharide-Induced Teratogenesis in Mice. Toxicol Sci. 2008 May103(1):149-57.

  [4]. Y Kotake, et al. Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX Catalytic Activity by phenyl-N-tert-butylnitrone (PBN). Biochim Biophys Acta. 1998 Nov 191448(1):77-84.

  [5]. R A Floyd. Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders. Proc Soc Exp Biol Med. 1999 Dec222(3):236-45.

N-叔丁基苯硝酮-D14物理化学性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 283.3±23.0 °C at 760 mmHg
• 分子式: C₁₁HD₁₄NO
• 分子量: 191.329
• 闪点: 118.5±15.4 °C
• 精确质量: 191.203232
• PSA: 28.75000
• LogP: 1.25
• InChIKey: IYSYLWYGCWTJSG-IJUZYFTRSA-N
• SMILES: CC(C)(C)[N+]([O-])=Cc1ccccc1
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.552

N-叔丁基苯硝酮-D14靶点实验

查看更多实验

实验名称：Cytotoxicity against mouse 3T3 cells assessed as cell viability after 3 hrs by spectr... 来源：ChEMBL 靶标：NIH3T3 External Id：CHEMBL2330078

实验名称：Cytotoxicity against human A549 cells assessed as reduction in cell viability measure... 来源：ChEMBL 靶标：A549 External Id：CHEMBL3826551

实验名称：Drug uptake in Sprague-Dawley rat liver cytosol incubated for 1 hr followed by compou... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2330077

实验名称：Cytotoxicity against human A549 cells assessed as reduction in cell viability measure... 来源：ChEMBL 靶标：A549 External Id：CHEMBL3826552

实验名称：Drug uptake in Sprague-Dawley rat liver mitochondria incubated for 1 hr followed by c... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2330076

实验名称：Cytotoxicity against BAEC assessed as reduction in cell viability measured after 24 h... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3826553

实验名称：Toxicity against Sprague-Dawley rat liver assessed as ATP content incubated for 1 hr ... 来源：ChEMBL 靶标：Liver External Id：CHEMBL2330075

实验名称：Cytotoxicity against BAECs assessed as decrease in total intracellular LDH content at... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3824751

实验名称：Toxicity against Chlamydomonas reinhardtii D66 assessed as loss of photosynthetic act... 来源：ChEMBL 靶标：N/A External Id：CHEMBL2330082

实验名称：Antioxidant activity assessed as inhibition of allopurinol-xanthine oxidase system-me... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3826547

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N-叔丁基苯硝酮-D14英文别名

• Phenyl-n-propyl-dimethylsilan
• N-[2-(H)Methyl(H)-2-propanyl]-N-[(Z)-(H)phenylmethylene]amine oxide
• phenyl-N-tert-butylnitrone-d14
• Silane,dimethylphenylpropyl
• Dimethyl-phenyl-n-propylsilan
• Phenyl-dimethyl-propyl-silan
• N-[2-(H)Methyl(H)propan-2-yl]-N-[(Z)-(H)phenylmethylene]amine oxide