依利罗地

• 常用名: 依利罗地
• 英文名: Eliprodil
• CAS号: 119431-25-3
• 分子量: 347.85400
• 密度: 1.205 g/cm3
• 沸点: 474.1ºC at 760 mmHg
• 分子式: C₂₀H₂₃ClFNO
• 熔点: N/A
• 闪点: 240.5ºC
• 符号: GHS07, GHS09
• 信号词: Warning

依利罗地用途

Eliprodil(SL-820715)是NR2B-NMDA受体高效选择性抑制剂,IC50值1uM,对NR2A-和NR2C-NMDA受体作用弱。

依利罗地名称

• 中文名: 依利罗地
• 英文名: Eliprodil,α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol

依利罗地生物活性

• 描述: Eliprodil(SL-820715)是NR2B-NMDA受体高效选择性抑制剂,IC50值1uM,对NR2A-和NR2C-NMDA受体作用弱。
• 相关类别:
  信号通路 >> 跨膜转运 >> iGluR
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Bath CP, et al. The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia. Eur J Pharmacol. 1996 Mar 28;299(1-3):103-12.

  [2]. Lengyel C, et al. Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk. Br J Pharmacol. 2004 Sep;143(1):152-8.

依利罗地物理化学性质

• 密度: 1.205 g/cm3
• 沸点: 474.1ºC at 760 mmHg
• 分子式: C₂₀H₂₃ClFNO
• 分子量: 347.85400
• 闪点: 240.5ºC
• 精确质量: 347.14500
• PSA: 23.47000
• LogP: 4.40510
• InChIKey: GGUSQTSTQSHJAH-UHFFFAOYSA-N
• SMILES: OC(CN1CCC(Cc2ccc(F)cc2)CC1)c1ccc(Cl)cc1
• 外观性状: 固体
• 蒸汽压: 8.57E-10mmHg at 25°C
• 折射率: 1.58
• 储存条件: 2-8°C

依利罗地安全信息

• 符号: GHS07, GHS09
• 信号词: Warning
• 危害声明: H319-H410
• 警示性声明: P273-P305 + P351 + P338-P501
• 个人防护装备: Eyeshields;Gloves
• 危害码 (欧洲): N: Dangerous for the environment;
• 风险声明 (欧洲): R50/53
• 安全声明 (欧洲): 60-61
• 危险品运输编码: UN 3077 9/PG 3
• 海关编码: 2933399090

依利罗地海关

• 海关编码: 2933399090
• 中文概述: 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

依利罗地靶点实验

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依利罗地英文别名

• eliprodil