UNC0224

• 常用名: UNC0224
• 英文名: UNC 0224
• CAS号: 1197196-48-7
• 分子量: 485.665
• 密度: 1.1±0.1 g/cm3
• 沸点: 641.0±65.0 °C at 760 mmHg
• 分子式: C₂₆H₄₃N₇O₂
• 熔点: N/A
• 闪点: 341.5±34.3 °C

UNC0224用途

UNC0224是G9a抑制剂,IC50为15 nM。

UNC0224名称

• 中文名: UNC0224
• 英文名: 7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

UNC0224生物活性

• 描述: UNC0224是G9a抑制剂,IC50为15 nM。
• 相关类别:
  信号通路 >> 表观遗传学 >> 组蛋白甲基转移酶
  研究领域 >> 癌症
• 参考文献:

  [1]. Liu F, et al. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J Med Chem. 2009 Dec 24;52(24):7950-3.

  [2]. Liu F, et al. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53(15):5844-57.

UNC0224物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 641.0±65.0 °C at 760 mmHg
• 分子式: C₂₆H₄₃N₇O₂
• 分子量: 485.665
• 闪点: 341.5±34.3 °C
• 精确质量: 485.347809
• PSA: 69.23000
• LogP: 1.30
• InChIKey: XIVUGRBSBIXXJE-UHFFFAOYSA-N
• SMILES: COc1cc2c(NC3CCN(C)CC3)nc(N3CCCN(C)CC3)nc2cc1OCCCN(C)C
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.589
• 储存条件: 2-8℃

UNC0224靶点实验

查看更多实验

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Inhibition of EHMT1/2 in human AsPC1 cells assessed as H3K9Me2 level at 10 uM incubat... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EHMT1 External Id：CHEMBL4350286

实验名称：Selectivity ratio of IC50 for N-terminal GST tagged human recombinant EHMT2 (785 to 1... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4350285

实验名称：Inhibition of N-terminal GST tagged human recombinant EHMT2 (785 to 1210 residues) ex... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EHMT2 External Id：CHEMBL4350284

实验名称：Inhibition of N-terminal GST tagged human recombinant EHMT1 (794 to 1294 residues) ex... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EHMT1 External Id：CHEMBL4350283

实验名称：qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1):... 来源：NCGC 靶标：thioredoxin reductase [Rattus norvegicus] External Id：TRXR101

实验名称：qHTS drug screen for cell cycle checkpoint inhibitors in PARPi-resistant BRCA-mutant ... 来源：NCGC External Id：FGL-PARP_PEO-CTG96h-MIPE5.0-p1

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UNC0224英文别名

• 7-[3-(Dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methyl-4-piperidinyl)-4-quinazolinamine
• 7-[3-(Dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
• unc0224
• UNC-0224