UNC 0224

Modify Date: 2024-01-03 09:03:27

UNC 0224 Structure
UNC 0224 structure
 Common Name UNC 0224
CAS Number 1197196-48-7 Molecular Weight 485.665
Density 1.1±0.1 g/cm3 Boiling Point 641.0±65.0 °C at 760 mmHg
Molecular Formula C26H43N7O2 Melting Point N/A
MSDS N/A Flash Point 341.5±34.3 °C

 Use of UNC 0224


UNC0224 is a potent and selective G9a inhibitor with IC50 of 15 nM in the G9a Thioglo assay.IC50 value: 15 nM [1]Target: G9aUNC0224 (Compound 8) also potently inhibited GLP with an IC50 of 20 nM and 58 nM in the Thioglo assay and and AlphaScreen, respectively. 8 was more than 1000-fold selective for G9a over SET7/9 (a H3K4 HMT) and SET8/PreSET7 (a H4K20 HMT) in Thioglo-based biochemical assays [1] [2].

 Names

Name 7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
Synonym More Synonyms

 UNC 0224 Biological Activity

Description UNC0224 is a potent and selective G9a inhibitor with IC50 of 15 nM in the G9a Thioglo assay.IC50 value: 15 nM [1]Target: G9aUNC0224 (Compound 8) also potently inhibited GLP with an IC50 of 20 nM and 58 nM in the Thioglo assay and and AlphaScreen, respectively. 8 was more than 1000-fold selective for G9a over SET7/9 (a H3K4 HMT) and SET8/PreSET7 (a H4K20 HMT) in Thioglo-based biochemical assays [1] [2].
Related Catalog
References

[1]. Liu F, et al. Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a. J Med Chem. 2009 Dec 24;52(24):7950-3.

[2]. Liu F, et al. Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53(15):5844-57.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 641.0±65.0 °C at 760 mmHg
Molecular Formula C26H43N7O2
Molecular Weight 485.665
Flash Point 341.5±34.3 °C
Exact Mass 485.347809
PSA 69.23000
LogP 1.30
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.589
Storage condition 2-8℃

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

7-[3-(Dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methyl-4-piperidinyl)-4-quinazolinamine
4-quinazolinamine, 7-[3-(dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-
7-[3-(Dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
unc0224
UNC-0224
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Chemsrc provides UNC 0224(CAS#:1197196-48-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of UNC 0224 are included as well.>> amp version: UNC 0224

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