右氯谷胺

更新时间：2025-08-25 18:07:21

右氯谷胺结构式	常用名	右氯谷胺	英文名	Dexloxiglumide
	CAS号	119817-90-2	分子量	461.37900
	密度	1.233g/cm3	沸点	632.2ºC at 760mmHg
	分子式	C₂₁H₃₀Cl₂N₂O₅	熔点	N/A
	MSDS	N/A	闪点	336.1ºC

右氯谷胺用途

Dexloxiglumide 是一种选择性的胆囊收缩素 A 型 (CCKA) 受体拮抗剂。Dexloxiglumide 是 Loxiglumide 的活性对映体,可抑制胆囊收缩素-八肽 (CCK-8) 诱导的平滑肌细胞收缩。

中文名	右氯谷胺
英文名	(4R)-4-[(3,4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic acid
英文别名	更多

描述	Dexloxiglumide 是一种选择性的胆囊收缩素 A 型 (CCKA) 受体拮抗剂。Dexloxiglumide 是 Loxiglumide 的活性对映体,可抑制胆囊收缩素-八肽 (CCK-8) 诱导的平滑肌细胞收缩。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 胆囊收缩素受体研究领域 >> 代谢疾病
参考文献	[1]. Scarpignato C, et al. Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: evaluation of their receptor selectivity in vivo. Aliment Pharmacol Ther. 1996 Jun;10(3):411-9. [2]. Maselli MA, et al. CCK1 receptor antagonist, dexloxiglumide: effects on human isolated gallbladder. Potential clinical applications. Minerva Gastroenterol Dietol. 2003 Sep;49(3):211-6.

描述

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 胆囊收缩素受体

研究领域 >> 代谢疾病

参考文献

[1]. Scarpignato C, et al. Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: evaluation of their receptor selectivity in vivo. Aliment Pharmacol Ther. 1996 Jun;10(3):411-9.

[2]. Maselli MA, et al. CCK1 receptor antagonist, dexloxiglumide: effects on human isolated gallbladder. Potential clinical applications. Minerva Gastroenterol Dietol. 2003 Sep;49(3):211-6.

密度	1.233g/cm3
沸点	632.2ºC at 760mmHg
分子式	C₂₁H₃₀Cl₂N₂O₅
分子量	461.37900
闪点	336.1ºC
精确质量	460.15300
PSA	95.94000
LogP	4.40280
InChIKey	QNQZBKQEIFTHFZ-GOSISDBHSA-N
SMILES	CCCCCN(CCCOC)C(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1
蒸汽压	7.51E-17mmHg at 25°C
折射率	1.537
储存条件	-20°C，密闭，干燥

危害码 (欧洲)	Xn,Xi

实验名称：Hepatic clearance in cynomolgus monkey at < 1 mg/kg, iv administered as cassette dosi...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4702831

实验名称：Fraction unbound in human plasma
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4702833

实验名称：Hepatic clearance in human administered through iv dosing
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4702832

实验名称：Lipophilicity, log D of the compound at pH 7.4 by by shake flask method
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4702823

实验名称：Apparent permeability in dog MDCKII-LE cells at pH 7.4
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4702822

实验名称：Intrinsic clearance in cryopreserved human hepatocytes at 1 uM measured up to 120 min...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4702824

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
来源：ChEMBL
靶标：Replicase polyprotein 1ab
External Id：CHEMBL4495582

实验名称：Fraction unbound in cynomolgus monkey plasma
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4702826

实验名称：Ratio of drug level in human blood to plasma administered through iv dosing by LC-MS/...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4702829

实验名称：Ratio of drug level in cynomolgus monkey blood to plasma administered through iv dosi...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4702828

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