VGSCs-IN-1

• 常用名: VGSCs-IN-1
• 英文名: VGSCs-IN-1
• CAS号: 1204296-79-6
• 分子量: 303.30
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₁₂F₃N₃OS
• 熔点: N/A
• 闪点: N/A

VGSCs-IN-1用途

VGSCs-IN-1 (compound 14) 是 Riluzole (HY-B0211) 的 2-哌嗪类似物,是一种人电压门控钠通道 (VGSC) 抑制剂。VGSCs-IN-1 显示出良好的 Nav1.4 阻断活性。VGSCs-IN-1 的 pKa 为 7.6,cLog P 为 2.4。VGSCs-IN-1可用于细胞兴奋性障碍研究。

VGSCs-IN-1名称

• 英文名: 2-(piperazin-1-yl)-6-(trifluoromethoxy)benzothiazole

VGSCs-IN-1生物活性

• 描述: VGSCs-IN-1 (compound 14) 是 Riluzole (HY-B0211) 的 2-哌嗪类似物,是一种人电压门控钠通道 (VGSC) 抑制剂。VGSCs-IN-1 显示出良好的 Nav1.4 阻断活性。VGSCs-IN-1 的 pKa 为 7.6,cLog P 为 2.4。VGSCs-IN-1可用于细胞兴奋性障碍研究。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钠通道
  研究领域 >> 神经疾病
• 靶点实验:

  hNav1.4

  hNav1.7

• 参考文献:

  [1]. Farinato A, et al. Development of Riluzole Analogs with Improved Use-Dependent Inhibition of Skeletal Muscle Sodium Channels. ACS Med Chem Lett. 2023 Jun 23;14(7):999-1008.

VGSCs-IN-1物理化学性质

• 分子式: C₁₂H₁₂F₃N₃OS
• 分子量: 303.30
• 精确质量: 303.06500
• PSA: 65.63000
• LogP: 2.99830
• InChIKey: IFWQLRCODRPXKE-UHFFFAOYSA-N
• SMILES: FC(F)(F)Oc1ccc2nc(N3CCNCC3)sc2c1

VGSCs-IN-1靶点实验

查看更多实验

实验名称：Analgesic activity in po dosed mouse assessed as licking latency at 77 uM measured af... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5363718

实验名称：Analgesic activity in po dosed mouse assessed as licking latency at 77 uM measured af... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5363719

实验名称：Analgesic activity in po dosed mouse assessed as licking latency at 77 uM measured af... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5363716

实验名称：Analgesic activity in po dosed mouse assessed as licking latency at 77 uM measured af... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL5363717

实验名称：Selectivity ratio of IC50 for human Nav 1.4 expressed in HEK293T cells assessed as to... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5363714

实验名称：Selectivity ratio of IC50 for human Nav 1.7 expressed in HEK293T cells assessed as to... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5363715

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