VU 0365114

• 常用名: VU 0365114
• 英文名: VU 0365114
• CAS号: 1208222-39-2
• 分子量: 397.34700
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₁₄F₃NO₃
• 熔点: N/A
• 闪点: N/A

VU 0365114用途

VU 0365114 是 mAChR M5 的正变构调节剂,其EC50 值为2.7 μM。

VU 0365114名称

• 中文名: VU 0365114
• 英文名: 1-(4-Biphenylylmethyl)-5-(trifluoromethoxy)-1H-indole-2,3-dione

VU 0365114生物活性

• 描述: VU 0365114 是 mAChR M5 的正变构调节剂,其EC50 值为2.7 μM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 其他
• 靶点实验:

  EC50: 2.7 μM (mAChR M5)[1].

• 参考文献:

  [1]. Bridges TM, et al. Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg Med Chem Lett. 2010 Oct 1;20(19):5617-22.

VU 0365114物理化学性质

• 分子式: C₂₂H₁₄F₃NO₃
• 分子量: 397.34700
• 精确质量: 397.09300
• PSA: 46.61000
• LogP: 5.04670
• InChIKey: SPBGRXOPAXZSER-UHFFFAOYSA-N
• SMILES: O=C1C(=O)N(Cc2ccc(-c3ccccc3)cc2)c2ccc(OC(F)(F)F)cc21
• 储存条件: 2-8℃

VU 0365114靶点实验

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