IEM-1460

• 常用名: IEM-1460
• 英文名: IEM-1460
• CAS号: 121034-89-7
• 分子量: 454.33
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₃₈Br₂N₂
• 熔点: N/A
• 闪点: N/A

IEM-1460用途

IEM-1460通过体内抗惊厥作用阻断AMPA和NMDA谷氨酸受体【1】。

IEM-1460名称

• 英文名: 5-(1-adamantylmethylamino)pentyl-trimethylazanium,bromide,hydrobromide

IEM-1460生物活性

• 描述: IEM-1460通过体内抗惊厥作用阻断AMPA和NMDA谷氨酸受体【1】。
• 相关类别:
  信号通路 >> 神经信号通路 >> iGluR
  研究领域 >> 神经疾病
  信号通路 >> 跨膜转运 >> iGluR
• 参考文献:

  [1]. Schlesinger F, et al. Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors. Br J Pharmacol. 2005 Jul;145(5):656-63.

IEM-1460物理化学性质

• 分子式: C₁₉H₃₈Br₂N₂
• 分子量: 454.33
• 精确质量: 452.140167
• PSA: 12.03000
• LogP: 2.02190
• InChIKey: CQTDZUSQSTUZDA-UHFFFAOYSA-M
• SMILES: Br.C[N+](C)(C)CCCCCNCC12CC3CC(CC(C3)C1)C2.[Br-]

IEM-1460靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (E... 来源：NCGC External Id：epac1-activator-v

实验名称：Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 3... 来源：NCGC External Id：epac1-inhibitor-v

实验名称：Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 4 (E... 来源：NCGC External Id：epac2-activator-v2

实验名称：Validation qHTS for antagonist of cAMP-regulated guanine nucleotide exchange factor 4... 来源：NCGC External Id：epac2-inhibitor-v2

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：LOPAC HTS for Inhibitors of Aerobactin Synthetase IucA 来源：23265 靶标：IucA from hypervirulent Klebsiella pneumoniae External Id：IucA Pilot Assay LOPAC Library

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IEM-1460英文别名

• 5-[(Adamantan-1-ylmethyl)amino]-N,N,N-trimethyl-1-pentanaminium bromide hydrobromide (1:1:1)
• 1-Pentanaminium, N,N,N-trimethyl-5-[(tricyclo[3.3.1.1]dec-1-ylmethyl)amino]-, bromide, hydrobromide (1:1:1)
• 5-[(Adamantan-1-ylmethyl)amino]-N,N,N-trimethylpentan-1-aminium bromide hydrobromide (1:1:1)
• Iem 1460
• Tocris-1636