Granisetron-d3

更新时间：2025-10-02 13:15:45

Granisetron-d3结构式	常用名	Granisetron-d3	英文名	Granisetron-d3
	CAS号	1224925-64-7	分子量	315.43
	密度	N/A	沸点	N/A
	分子式	C₁₈H₂₁D₃N₄O	熔点	N/A
	MSDS	N/A	闪点	N/A

Granisetron-d3用途

格拉司琼-d3(BRL 43694-d3)是氘标记的格拉司琼。格拉司琼(BRL 43694)是一种5-羟色胺-HT3受体拮抗剂,用作治疗化疗后恶心呕吐的止吐药[1][2]。

英文名	Granisetron-d3

描述	格拉司琼-d3(BRL 43694-d3)是氘标记的格拉司琼。格拉司琼(BRL 43694)是一种5-羟色胺-HT3受体拮抗剂,用作治疗化疗后恶心呕吐的止吐药[1][2]。
相关类别	研究领域 >> 神经疾病信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体信号通路 >> 神经信号通路 >> 5-HT受体
体外研究	氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Sanger GJ, Nelson DR. Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron). Eur J Pharmacol. 1989 Jan 10;159(2):113-24. [3]. Maleki-Dizaji N, Eteraf-Oskouei T, Fakhrjou A, The effects of 5HT3 receptor antagonist granisetron on inflammatory parameters and angiogenesis in the air-pouch model of inflammation. Int Immunopharmacol. 2010 Sep;10(9):1010-6. [4]. Boccia RV, Gordan LN, Clark G, Efficacy and tolerability of transdermal granisetron for the control of chemotherapy-induced nausea and vomiting associated with moderately and highly emetogenic multi-day chemotherapy: a randomized, double-blind, phase III study. Support Care Cancer. 2011 Oct;19(10):1609-17.

分子式	C₁₈H₂₁D₃N₄O
分子量	315.43
InChIKey	MFWNKCLOYSRHCJ-FIBGUPNXSA-N
SMILES	CN1C2CCCC1CC(NC(=O)c1nn(C)c3ccccc13)C2

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
来源：NCGC
External Id：SNCA-p-activity-luciferase

实验名称：In vivo effective dose against Bezold-Jarisch reflex evoked by 5-HT in urethane-anest...
来源：ChEMBL
靶标：Rattus norvegicus
External Id：CHEMBL779632

实验名称：Selectivity ratio of peroral vs intravenous delivery
来源：ChEMBL
靶标：5-hydroxytryptamine receptor 3B
External Id：CHEMBL846696

实验名称：Chemical stability of the compound assessed as half life
来源：ChEMBL
靶标：N/A
External Id：CHEMBL1285708

实验名称：Biodistribution in rat cerebellum, expressed as percent I.D./g tissue
来源：ChEMBL
靶标：Rattus norvegicus
External Id：CHEMBL625120

实验名称：Biodistribution in rat superior coliculus, expressed as percent I.D./g tissue
来源：ChEMBL
靶标：Rattus norvegicus
External Id：CHEMBL625121

实验名称：Biodistribution in rat thalamus, expressed as percent I.D./g tissue
来源：ChEMBL
靶标：Rattus norvegicus
External Id：CHEMBL625122

实验名称：Evaluated for the 5-hydroxytryptamine 4 receptor antagonistic activity in piglet atri...
来源：ChEMBL
靶标：5-hydroxytryptamine receptor 4
External Id：CHEMBL619015

实验名称：Inhibition of human ERG
来源：ChEMBL
靶标：Voltage-gated inwardly rectifying potassium channel KCNH2
External Id：CHEMBL1676103

实验名称：Hepatic clearance in human hepatocytes in absence of fetal calf serum
来源：ChEMBL
靶标：Hepatocyte
External Id：CHEMBL1001484

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