palmostalin B

• 常用名: palmostalin B
• 英文名: palmostalin B
• CAS号: 1233365-12-2
• 分子量: 376.53
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₃₆O₄
• 熔点: N/A
• 闪点: N/A

palmostalin B用途

Palmostatin B 是一种酰基蛋白硫酯酶 1 和 2 (APT-1, APT-2) 抑制剂。Palmostatin B 降低 NRAS 突变黑色素瘤细胞系的细胞活力。Palmostatin B 抑制细胞 Ras 去棕榈酰化。

palmostalin B名称

• 英文名: palmostalin B

palmostalin B生物活性

• 描述: Palmostatin B 是一种酰基蛋白硫酯酶 1 和 2 (APT-1, APT-2) 抑制剂。Palmostatin B 降低 NRAS 突变黑色素瘤细胞系的细胞活力。Palmostatin B 抑制细胞 Ras 去棕榈酰化。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> 磷脂
• 参考文献:

  [1]. Vujic I, et al. Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget. 2016 Feb 9;7(6):7297-306.

  [2]. Dekker FJ, et al. Small-molecule inhibition of APT1 affects Ras localization and signaling. Nat Chem Biol. 2010 Jun;6(6):449-56.

palmostalin B物理化学性质

• 分子式: C₂₃H₃₆O₄
• 分子量: 376.53
• 精确质量: 376.26100
• PSA: 44.76000
• LogP: 5.70880
• InChIKey: ASVWFAVGLYUDFD-PMACEKPBSA-N
• SMILES: CCCCCCCCCCC1C(=O)OC1CCc1ccc(OC)c(OC)c1

palmostalin B靶点实验

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实验名称：Ratio of IC50 for reversible inhibition of human ABHD16A expressed in HEK293 cells to... 来源：ChEMBL 靶标：Phosphatidylserine lipase ABHD16A External Id：CHEMBL4330043

实验名称：Inhibition of recombinant human ABHD16A expressed in HEK293T cells incubated for 1 hr... 来源：ChEMBL 靶标：Phosphatidylserine lipase ABHD16A External Id：CHEMBL5524615

实验名称：Potency index, ratio of tetrahydrolipstatin IC50 to compound IC50 for inhibition of A... 来源：ChEMBL 靶标：Phosphatidylserine lipase ABHD16A External Id：CHEMBL4330037

实验名称：Inhibition of APT2 (unknown origin) 来源：ChEMBL 靶标：Acyl-protein thioesterase 2 External Id：CHEMBL5524592

实验名称：Inhibition of APT1 (unknown origin) 来源：ChEMBL 靶标：Acyl-protein thioesterase 1 External Id：CHEMBL5524591

实验名称：Inhibition of APT1 (unknown origin) 来源：ChEMBL 靶标：Acyl-protein thioesterase 1 External Id：CHEMBL3135195

实验名称：Binding affinity to LYPLA2 in rat cerebellar membranes at 10 uM measured after 1 hr b... 来源：ChEMBL 靶标：Acyl-protein thioesterase 2 External Id：CHEMBL4330048

实验名称：Binding affinity to LYPLA1 in rat cerebellar membranes at 10 uM measured after 1 hr b... 来源：ChEMBL 靶标：Acyl-protein thioesterase 1 External Id：CHEMBL4330047

实验名称：Inhibition of TAMRA-FP binding to ABHD16A in rat cerebellar membranes at 10 uM preinc... 来源：ChEMBL 靶标：Phosphatidylserine lipase ABHD16A External Id：CHEMBL4330045

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palmostalin B英文别名

• palm. B
• palmostatin B
• PALMOSTATIN B