CAY10650

• 常用名: CAY10650
• 英文名: CAY10650
• CAS号: 1233706-88-1
• 分子量: 471.501
• 密度: 1.2±0.1 g/cm3
• 沸点: 685.4±55.0 °C at 760 mmHg
• 分子式: C₂₈H₂₅NO₆
• 熔点: N/A
• 闪点: 368.3±31.5 °C

CAY10650用途

CAY10650是cPLA2α抑制剂，IC50为12 nM。

CAY10650名称

• 中文名: 3-(2-甲基-1-氧代丙基)-1-[2-氧代-3-(4-苯氧基苯氧基)丙基]-1H-吲哚-5-羧酸
• 英文名: 3-isobutanoyl-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]indole-5-carboxylic acid

CAY10650生物活性

• 描述: CAY10650是cPLA2α抑制剂,IC50为12 nM。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷脂
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Tripathi T, et al. Role of phospholipase A 2(PLA2) inhibitors in attenuating apoptosis of the corneal epithelial cells and mitigation of Acanthamoeba keratitis. Exp Eye Res. 2013 Aug;113:182-91.

CAY10650物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 685.4±55.0 °C at 760 mmHg
• 分子式: C₂₈H₂₅NO₆
• 分子量: 471.501
• 闪点: 368.3±31.5 °C
• 精确质量: 471.168182
• PSA: 94.83000
• LogP: 4.63
• InChIKey: HTOJZPHWNDZOPQ-UHFFFAOYSA-N
• SMILES: CC(C)C(=O)c1cn(CC(=O)COc2ccc(Oc3ccccc3)cc2)c2ccc(C(=O)O)cc12
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.607
• 储存条件: 2-8℃

CAY10650靶点实验

查看更多实验

实验名称：Drug level in C57Bl6 mouse bile at 10 mg/kg, iv after 30 mins by HPLC/MS analysis in ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1118758

实验名称：Drug level in C57Bl6 mouse bile at 10 mg/kg, iv after 30 mins by by HPLC/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL1118757

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Drug level in C57Bl6 mouse plasma at 100 mg/kg, po after 2 hrs by UV-reverse phase HP... 来源：ChEMBL 靶标：Plasma External Id：CHEMBL1118754

实验名称：Drug level in C57Bl6 mouse plasma at 100 mg/kg, po after 1 hr by UV-reverse phase HPL... 来源：ChEMBL 靶标：Plasma External Id：CHEMBL1118753

实验名称：Drug level in C57Bl6 mouse plasma at 10 mg/kg, iv after 30 mins by UV-reverse phase H... 来源：ChEMBL 靶标：Plasma External Id：CHEMBL1118752

实验名称：Drug level in C57Bl6 mouse plasma at 10 mg/kg, iv after 5 mins by UV-reverse phase HP... 来源：ChEMBL 靶标：Plasma External Id：CHEMBL1118751

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Drug level in C57Bl6 mouse intestine assessed as 3-(5-Carboxypentanoyl)-1-[2-hydroxy-... 来源：ChEMBL 靶标：Intestine External Id：CHEMBL1806124

实验名称：Antiinflammatory activity in BALB/c mouse assessed as inhibition of benzalkonium chlo... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1118766

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CAY10650英文别名

• 1H-Pyrrole,3-iodo
• 3-Iodpyrrol
• 3-Isobutyryl-1-[2-oxo-3-(4-phenoxyphenoxy)propyl]-1H-indole-5-carboxylic acid
• 3-IODOPYRROLE
• CAY10650