PNU-282987

• 常用名: PNU-282987
• 英文名: PNU 282987
• CAS号: 123464-89-1
• 分子量: 301.21
• 密度: 1.3±0.1 g/cm3
• 沸点: 431.5±30.0 °C at 760 mmHg
• 分子式: C₁₄H₁₈Cl₂N₂O
• 熔点: N/A
• 闪点: 214.8±24.6 °C

PNU-282987用途

PNU-282987是_alpha_7 nAChR受体选择性激动剂，Ki值为26nM，对_alpha_1_beta_1_gamma__delta_和_alpha_3_beta_4nAChRs亲和力弱。

PNU-282987名称

• 中文名: N-(3R)-1-氮杂双环[2,2,2]辛-3-基-4-氯苯甲酰胺盐酸盐
• 英文名: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide

PNU-282987生物活性

• 描述: PNU-282987是_alpha_7 nAChR受体选择性激动剂,Ki值为26nM,对_alpha_1_beta_1_gamma__delta_和_alpha_3_beta_4nAChRs亲和力弱。
• 相关类别:
  信号通路 >> 跨膜转运 >> 胆碱受体
  信号通路 >> 神经信号通路 >> 胆碱受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Bodnar AL, et al. Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8.

  [2]. Li F, et al. The protective effect of PNU-282987, a selective α7 nicotinic acetylcholine receptor agonist, on the hepatic ischemia-reperfusion injury is associated with the inhibition of high-mobility group box 1 protein expression and nuclear factor κB activation in mice. Shock. 2013 Feb;39(2):197-203.

  [3]. Stuckenholz V, et al. The α7 nAChR agonist PNU-282987 reduces inflammation and MPTP-induced nigral dopaminergic cell loss in mice. J Parkinsons Dis. 2013;3(2):161-72.

  [4]. Mesa-Gresa P, et al. Behavioral effects of different enriched environments in mice treated with the cholinergic agonist PNU-282987. Behav Processes. 2014 Mar;103:117-24.

  [5]. Dong Jun Yu, et al. Effect of ischemic preconditioning combined with α7 nAchR agonists on limb ischemia-reperfusion lung injury in rat. Biomed Res. 2017; Special Issue: ISSN 0970.

PNU-282987物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 431.5±30.0 °C at 760 mmHg
• 分子式: C₁₄H₁₈Cl₂N₂O
• 分子量: 301.21
• 闪点: 214.8±24.6 °C
• PSA: 32.34000
• LogP: 2.49
• InChIKey: HSEQUIRZHDYOIX-ZOWNYOTGSA-N
• SMILES: Cl.O=C(NC1CN2CCC1CC2)c1ccc(Cl)cc1
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.612
• 储存条件: 2-8℃

PNU-282987靶点实验

查看更多实验

实验名称：qHTS assay to identify small molecule antagonists of the estrogen related receptor (E... 来源：824 靶标：N/A External Id：ERR513

实验名称：qHTS assay to identify small molecule antagonists of the estrogen related receptor (E... 来源：824 External Id：ERR845

实验名称：Inhibition of [3H]cytisine binding to Nicotinic acetylcholine receptor alpha4-beta2 f... 来源：ChEMBL 靶标：Neuronal acetylcholine receptor subunit alpha-4 External Id：CHEMBL834843

实验名称：qHTS assay to identify small molecule antagonists of the estrogen related receptor si... 来源：824 靶标：N/A External Id：PGC981

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实验名称：qHTS assay to identify small molecule agonists of the estrogen related receptor (ERR)... 来源：824 External Id：ERR136

实验名称：qHTS assay to identify small molecule antagonists of the estrogen related receptor si... 来源：824 External Id：PGC756

实验名称：Small-molecule inhibitors of ST2 (IL1RL1) 来源：20881 靶标：interleukin-1 receptor-like 1 isoform [homo sapiens] External Id：ST2_IL33_Inhibitors_Primary_Screening_77700

实验名称：qHTS assay for measurement of the activity of small molecule inhibitors on Zika virus... 来源：NCGC 靶标：N/A External Id：ZIK097

实验名称：LOPAC HTS for Inhibitors of Aerobactin Synthetase IucA 来源：23265 靶标：IucA from hypervirulent Klebsiella pneumoniae External Id：IucA Pilot Assay LOPAC Library

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PNU-282987英文别名

• PNU-282987
• N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide
• Kisspeptin 234