PNU 282987
Modify Date: 2024-01-02 16:14:00
PNU 282987 structure
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Common Name | PNU 282987 | ||
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| CAS Number | 123464-89-1 | Molecular Weight | 301.21 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 431.5±30.0 °C at 760 mmHg | |
| Molecular Formula | C14H18Cl2N2O | Melting Point | N/A | |
| MSDS | USA | Flash Point | 214.8±24.6 °C | |
Use of PNU 282987PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).IC50 value: 26 nM(Ki) [1]Target: α7 nAChR agonistin vitro: Treatment with PNU-282987 resulted in an attenuation of neuroinflammation in the MPTP-lesioned SN. Furthermore, PNU-282987 attenuated MPTP-induced dopaminergic cell loss in the SN and reduced striatal dopamine depletion [3].in vivo: Mice were subjected to 70% partial hepatic I/R for 60 min and pretreated with either vehicle or with PNU-282987, and blood and hepatic tissue samples were collected at 3, 6, and 12 h following reperfusion. pretreatment with PNU-282987 decreased serum transaminase levels and ameliorated liver injury after hepatic I/R. Moreover, pretreatment with PNU-282987 suppressed NF-κB activation, cytokine production (tumor necrosis factor α, interleukin 1β), and HMGB1 expression in liver after hepatic I/R [2]. Mice treated with 2.5 and 10 mg/kg of PNU devoted less time to rearing into open arms. In the HB task, MC mice displayed higher exploratory activity reflected in more head-dips (HD) during the first minute than EE and SE, whereas EE displayed low exploration levels reflected in total HD (5 min) [4]. |
| Name | N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide |
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| Synonym | More Synonyms |
| Description | PNU-282987 is a selective α7 nicotinic acetylcholine receptor(α7 nAChR) agonist with Ki of 26 nM; no affinity for α1β1γδ and α3β4 nAChRs (IC50 ≥ 60 μM).IC50 value: 26 nM(Ki) [1]Target: α7 nAChR agonistin vitro: Treatment with PNU-282987 resulted in an attenuation of neuroinflammation in the MPTP-lesioned SN. Furthermore, PNU-282987 attenuated MPTP-induced dopaminergic cell loss in the SN and reduced striatal dopamine depletion [3].in vivo: Mice were subjected to 70% partial hepatic I/R for 60 min and pretreated with either vehicle or with PNU-282987, and blood and hepatic tissue samples were collected at 3, 6, and 12 h following reperfusion. pretreatment with PNU-282987 decreased serum transaminase levels and ameliorated liver injury after hepatic I/R. Moreover, pretreatment with PNU-282987 suppressed NF-κB activation, cytokine production (tumor necrosis factor α, interleukin 1β), and HMGB1 expression in liver after hepatic I/R [2]. Mice treated with 2.5 and 10 mg/kg of PNU devoted less time to rearing into open arms. In the HB task, MC mice displayed higher exploratory activity reflected in more head-dips (HD) during the first minute than EE and SE, whereas EE displayed low exploration levels reflected in total HD (5 min) [4]. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 431.5±30.0 °C at 760 mmHg |
| Molecular Formula | C14H18Cl2N2O |
| Molecular Weight | 301.21 |
| Flash Point | 214.8±24.6 °C |
| PSA | 32.34000 |
| LogP | 2.49 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.612 |
| Storage condition | 2-8℃ |
| PNU-282987 |
| N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide |
| Kisspeptin 234 |
| Benzamide, N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-4-chloro- |