HPGDS-IN-1

• 常用名: HPGDS-IN-1
• 英文名: hPGDS-IN-1
• CAS号: 1234708-04-3
• 分子量: 416.43300
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₀N₆O₃
• 熔点: N/A
• 闪点: N/A

HPGDS-IN-1用途

hPGDS-IN-1是一种hPGDS抑制剂, 荧光偏振检测或EIA法测得IC50值为12 nM。

HPGDS-IN-1名称

• 中文名: HPGDS-IN-1
• 英文名: 2-(pyridin-2-yl)pyrimidine-5-carboxylic acid 3-[5-(1-hydroxy-1-methylethyl)-1,2,4]oxadiazol-3-yl-benzylamide

HPGDS-IN-1生物活性

• 描述: hPGDS-IN-1是一种hPGDS抑制剂, 荧光偏振检测或EIA法测得IC50值为12 nM。
• 相关类别:
  信号通路 >> 免疫及炎症 >> PGE合成酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Vandeusen, Christopher L, et al. Phenyloxadiazole derivatives as PGD inhibitors and their preparation, pharmaceutical compositions and use in the treatment of allergic and inflammatory disorders. From PCT Int. Appl. (2011), WO 2011044307 A1 20110414.

  [2]. Hahn Chang S. Method for treating macular degeneration using syk multikinase inhibitor, an hPGDS inhibitor and a DP antagonist. From PCT Int. Appl. (2010), WO 2010080563 A2 20100715.

  [3]. Weiberth Franz J, et al. Demonstration on Pilot-Plant Scale of the Utility of 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) as a Catalyst in the Efficient Amidation of an Unactivated Methyl Ester. From Organic Process Research & Development (2012), 16(12), 19

HPGDS-IN-1物理化学性质

• 分子式: C₂₂H₂₀N₆O₃
• 分子量: 416.43300
• 精确质量: 416.16000
• PSA: 126.92000
• LogP: 3.13690
• InChIKey: VJCLAPUACUQZOV-UHFFFAOYSA-N
• SMILES: CC(C)(O)c1nc(-c2cccc(CNC(=O)c3cnc(-c4ccccn4)nc3)c2)no1
• 储存条件: 2-8℃

HPGDS-IN-1靶点实验

查看更多实验

实验名称：Binding affinity to HPGDS (unknown origin) assessed as change in melting temperature ... 来源：ChEMBL 靶标：Hematopoietic prostaglandin D synthase External Id：CHEMBL4724450

实验名称：Binding affinity to HPGDS (unknown origin) assessed as change in melting temperature ... 来源：ChEMBL 靶标：Hematopoietic prostaglandin D synthase External Id：CHEMBL4724451

实验名称：Enzyme Immunoassay (EIA) Assay from US Patent US9469627: "Phenyloxadiazole derivative... 来源：BindingDB 靶标：N/A External Id：BindingDB_8464_1

实验名称：Inhibition of HPGDS (unknown origin) by fluorescence polarization assay 来源：ChEMBL 靶标：Hematopoietic prostaglandin D synthase External Id：CHEMBL4724449

实验名称：Inhibition of HPGDS (unknown origin) assessed as reduction in reduction in GSTase act... 来源：ChEMBL 靶标：Hematopoietic prostaglandin D synthase External Id：CHEMBL4724452

实验名称：Inhibition of HPGDS (unknown origin) assessed as reduction in reduction in LPS-induce... 来源：ChEMBL 靶标：Hematopoietic prostaglandin D synthase External Id：CHEMBL4724453

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HPGDS-IN-1英文别名

• 2-pyridin-2-yl-pyrimidine-5-carboxylic acid 3-[5-(1-hydroxy-1-methyl-ethyl)-1,2,4-oxadiazol-3-yl]benzylamide
• SAR-191801
• hPGDS-IN-1